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@article{983340,
author = {Máchalová, Alena and Šlais, Karel and Vrskova, Dagmar and Šulcová, Alexandra},
article_location = {Oxford, UK},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.pbb.2012.04.013},
keywords = {Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice},
language = {eng},
issn = {0091-3057},
journal = {Pharmacology Biochemistry and Behavior},
title = {Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice},
url = {http://www.sciencedirect.com/science/article/pii/S0091305712001232},
volume = {102},
year = {2012}
}
TY - JOUR
ID - 983340
AU - Máchalová, Alena - Šlais, Karel - Vrskova, Dagmar - Šulcová, Alexandra
PY - 2012
TI - Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
JF - Pharmacology Biochemistry and Behavior
VL - 102
IS - 2
SP - 215-223
EP - 215-223
PB - Elsevier Science Inc.
SN - 00913057
KW - Psychostimulant
KW - Modafinill
KW - Methamphetamine
KW - MDMA
KW - Agnostic behavior
KW - Mice
UR - http://www.sciencedirect.com/science/article/pii/S0091305712001232
L2 - http://www.sciencedirect.com/science/article/pii/S0091305712001232
N2 - The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).
ER -
MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA a Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. \textit{Pharmacology Biochemistry and Behavior}. Oxford, UK: Elsevier Science Inc., 2012, roč.~102, č.~2, s.~215-223. ISSN~0091-3057. Dostupné z: https://dx.doi.org/10.1016/j.pbb.2012.04.013.
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