Differential effects of modafinil, methamphetamine, and MDMA on
agonistic behavior in male mice

J 2012

Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA and Alexandra ŠULCOVÁ

Basic information

Original name

Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

Authors

MÁCHALOVÁ, Alena (203 Czech Republic, belonging to the institution), Karel ŠLAIS (203 Czech Republic, belonging to the institution), Dagmar VRSKOVA (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Pharmacology Biochemistry and Behavior, Oxford, UK, Elsevier Science Inc. 2012, 0091-3057

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.608

RIV identification code

RIV/00216224:14740/12:00060033

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.pbb.2012.04.013

UT WoS

000306776000006

Keywords in English

Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice

Abstract

V originále

The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA and Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. Pharmacology Biochemistry and Behavior. Oxford, UK: Elsevier Science Inc., 2012, vol. 102, No 2, p. 215-223. ISSN 0091-3057. Available from: https://dx.doi.org/10.1016/j.pbb.2012.04.013.

@article{983340,
   author = {Máchalová, Alena and Šlais, Karel and Vrskova, Dagmar and Šulcová, Alexandra},
   article_location = {Oxford, UK},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.pbb.2012.04.013},
   keywords = {Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice},
   language = {eng},
   issn = {0091-3057},
   journal = {Pharmacology Biochemistry and Behavior},
   title = {Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice},
   url = {http://www.sciencedirect.com/science/article/pii/S0091305712001232},
   volume = {102},
   year = {2012}
}

TY  - JOUR
ID  - 983340
AU  - Máchalová, Alena - Šlais, Karel - Vrskova, Dagmar - Šulcová, Alexandra
PY  - 2012
TI  - Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
JF  - Pharmacology Biochemistry and Behavior
VL  - 102
IS  - 2
SP  - 215-223
EP  - 215-223
PB  - Elsevier Science Inc.
SN  - 00913057
KW  - Psychostimulant
KW  - Modafinill
KW  - Methamphetamine
KW  - MDMA
KW  - Agnostic behavior
KW  - Mice
UR  - http://www.sciencedirect.com/science/article/pii/S0091305712001232
L2  - http://www.sciencedirect.com/science/article/pii/S0091305712001232
N2  - The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).
ER  -

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA and Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. \textit{Pharmacology Biochemistry and Behavior}. Oxford, UK: Elsevier Science Inc., 2012, vol.~102, No~2, p.~215-223. ISSN~0091-3057. Available from: https://dx.doi.org/10.1016/j.pbb.2012.04.013.

Detailed Information on Publication Record