GURECKÝ, Libor, Zdeňka BALCAROVÁ, Iveta PILAŘOVÁ and Libuše TRNKOVÁ. ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES. In XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Brno: Mendelova univerzita v Brně, 2012, p. 64-65. ISBN 978-80-7375-618-5.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES
Authors GURECKÝ, Libor (203 Czech Republic, belonging to the institution), Zdeňka BALCAROVÁ (203 Czech Republic, belonging to the institution), Iveta PILAŘOVÁ (203 Czech Republic, belonging to the institution) and Libuše TRNKOVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Brno, XII. Pracovní setkání fyzikálních chemiků a elektrochemiků, p. 64-65, 2 pp. 2012.
Publisher Mendelova univerzita v Brně
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10403 Physical chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14740/12:00057421
Organization unit Central European Institute of Technology
ISBN 978-80-7375-618-5
Keywords in English cytosine;oligonucleotides;cyclic voltammetry;elimination voltammetry
Tags rivok
Changed by Changed by: Mgr. Nikola Kostlánová, Ph.D., učo 12689. Changed: 12/4/2013 14:44.
Abstract
Cytosine-rich oligodeoxynucleotides (C-rich ODNs) play diverse roles in the regulation of protein expression at both transcriptional and translational levels. A repetitive C sequence can be responsible for some diseases. It is commonly known that C-rich ODNs form the stable i-motif structure, interesting due to a crucial role in the process of genetic information transfer. The aim of this contribution is to find out the relationship between the structure of homo-ODNs in buffered solutions with the same ionic strength (I = 0.18 M) but with a different number of cytosines (dCx; x = 3, 4, 5, 6, 9). Using linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS), electrochemical reduction signals studied on a mercury electrode reflect the conformation changes of the C-rich ODN chain.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
GD106/09/H035, research and development projectName: Víceúrovňový design pokrokových materiálů
Investor: Czech Science Foundation
PrintDisplayed: 19/7/2024 22:24