VOLFOVÁ, Pavlína, Martina LENGEROVÁ, Jana WINTEROVÁ, Zdeněk RÁČIL, Dana DVOŘÁKOVÁ and Jiří MAYER. Monitoring of Epstein–Barr virus load in patients after allogeneic hematopoietic stem cell transplantation. Infection. Mnichov: Springer-Verlag, 2012, vol. 40, No 5, p. 583-587. ISSN 0300-8126. doi:10.1007/s15010-012-0262-5.
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Basic information
Original name Monitoring of Epstein–Barr virus load in patients after allogeneic hematopoietic stem cell transplantation
Authors VOLFOVÁ, Pavlína (203 Czech Republic, belonging to the institution), Martina LENGEROVÁ (203 Czech Republic, guarantor, belonging to the institution), Jana WINTEROVÁ (703 Slovakia, belonging to the institution), Zdeněk RÁČIL (203 Czech Republic, belonging to the institution), Dana DVOŘÁKOVÁ (203 Czech Republic, belonging to the institution) and Jiří MAYER (203 Czech Republic, belonging to the institution).
Edition Infection, Mnichov, Springer-Verlag, 2012, 0300-8126.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.440
RIV identification code RIV/00216224:14110/12:00060057
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s15010-012-0262-5
UT WoS 000309340400017
Keywords in English Epstein–Barr virus; hematopoietic stem cell transplantation
Tags International impact
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 19. 2. 2013 23:31.
Abstract
Based on our results, we recommend the weekly monitoring of patients for at least 3 months after HSCT (2 out of 4 patients with EBV-associated disease passed the cut-off at week 11) and longer in patients with GVHD, due to the rapid progression of EBV infection, particularly in patients who develop clinical symptoms (lymphadenopathy, hepatosplenomegaly, or organ manifestations) related to EBV disease according to the European Conference on Infections in Leukemia (ECIL) 2011 guidelines. EBV reactivation occurred in some of the patients suffering fromGVHDin this cohort, but did not require clinical intervention unless the copy numbers were steadily increasing. A stable EBV viral load\1,000 copies/lg DNA temporarily occurred in some patients after HSCT; however, clinical symptoms of EBV infection did not develop and they did not require therapeutic intervention. Therefore, to improve the diagnostic value of EBV monitoring, the load measurement and quantitative monitoring of viral load kinetics is necessary.
Links
MSM0021622430, plan (intention)Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
MUNI/A/0784/2011, interní kód MUName: Nové diagnostické a klinické přístupy v onkologii (Acronym: NoDiKliPO)
Investor: Masaryk University, Category A
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