MicroRNAs and their target gene networks in renal cell carcinoma

RÉDOVÁ, Martina, Marek SVOBODA and Ondřej SLABÝ. MicroRNAs and their target gene networks in renal cell carcinoma. Biochem Biophys Res Commun. San Diego: Elsevier Science, vol. 405, No 2, p. 153-156. ISSN 0006-291X. doi:10.1016/j.bbrc.2011.01.019. 2011.

Basic information

• Original name: MicroRNAs and their target gene networks in renal cell carcinoma
• Authors: RÉDOVÁ, Martina (203 Czech Republic), Marek SVOBODA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Biochem Biophys Res Commun, San Diego, Elsevier Science, 2011, 0006-291X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.484
• RIV identification code: RIV/00216224:14740/11:00060083
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.bbrc.2011.01.019
• UT WoS: 000287627500001
• Keywords in English: MicroRNA; Renal cell carcinoma; Hypoxia; Epithelial-mesenchymal transition; Proliferation; Apoptosis
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

MiRNAs are related to the processes of cell proliferation, apoptosis, angiogenesis, invasion, and metastasis in RCC. MiRNAs expression profiles are associated with several RCC-specific genetic alterations. It has been well documented that several miRNAs are downstream effector molecules of the HIF-induced hypoxia response. MiR-200 family is linked to epithelial-mesenchymal transition which is one of the most significant pathogenetic mechanism in RCC. Mechanistic studies in RCC have provided the rationale of using miRNAs as potential therapeutic targets.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology