The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy

PAIL, Martin, Radek MAREČEK, Markéta HERMANOVÁ, Bronislava SLANÁ, Ivana TYRLÍKOVÁ, Robert KUBA and Milan BRÁZDIL. The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy. Epilepsia. Hoboken (NJ, USA): WILEY-BLACKWELL, 2012, vol. 53, No 6, p. 1004-1012. ISSN 0013-9580. Available from: https://dx.doi.org/10.1111/j.1528-1167.2012.03456.x.

Basic information

• Original name: The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy
• Authors: PAIL, Martin (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Bronislava SLANÁ (203 Czech Republic, belonging to the institution), Ivana TYRLÍKOVÁ (203 Czech Republic, belonging to the institution), Robert KUBA (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Epilepsia, Hoboken (NJ, USA), WILEY-BLACKWELL, 2012, 0013-9580.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.909
• RIV identification code: RIV/00216224:14740/12:00060088
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1111/j.1528-1167.2012.03456.x
• UT WoS: 000304715900012
• Keywords in English: Hippocampal sclerosis; Malformations of cortical development; Focal cortical dysplasias; Mesial temporal lobe epilepsy; Voxel-based morphometry; Temporal pole
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Purpose: To determine whether voxel-based morphometry (VBM) might contribute to the detection of cortical dysplasia within the temporal pole in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE/ HS). Key Findings: Histopathologic examination revealed cortical dysplasia within the temporal pole in 11 patients. Significance: We found that VBM made a superior contribution to the detection of temporopolar structural malformations (cortical dysplasia) compared to visual inspection. The agreement with postoperative histopathologic proof was clearly significant for VBM results and nonsignificant for visual inspection.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.