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@inproceedings{984158,
author = {Babula, Petr and Vančo, Jan and Krejčová, Ludmila and Hynek, David and Sochor, Jiří and Adam, Vojtěch and Trnková, Libuše and Hubálek, Jaromír and Kizek, René},
address = {Brno},
booktitle = {XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků.},
keywords = {metal complexes;cytotoxicity;copper;pyridine;aminopyridine;pyrazole;cyclic voltammetry;diferential pulse voltammetry;DNA},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Brno},
isbn = {978-80-7375-618-5},
pages = {177-179},
publisher = {Mendelova univerzita v Brně},
title = {VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES},
year = {2012}
}
TY - JOUR
ID - 984158
AU - Babula, Petr - Vančo, Jan - Krejčová, Ludmila - Hynek, David - Sochor, Jiří - Adam, Vojtěch - Trnková, Libuše - Hubálek, Jaromír - Kizek, René
PY - 2012
TI - VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES
PB - Mendelova univerzita v Brně
CY - Brno
SN - 9788073756185
KW - metal complexes;cytotoxicity;copper;pyridine;aminopyridine;pyrazole;cyclic voltammetry;diferential pulse voltammetry;DNA
N2 - Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we were focused on electrochemical behaviour of seven newly prepared complexes of lawsone with the second ligand represented by derivatives of pyridine, aminopyridine and pyrazole with copper(II) ions using methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA. Our results indicate that the most simple complex of lawsone - Cu(lawsone)2(H2O)20.5H2O proved significant prooxidant properties, which may contribute to its cytotoxicity that has been demonstrated in recent literature.
ER -
BABULA, Petr, Jan VANČO, Ludmila KREJČOVÁ, David HYNEK, Jiří SOCHOR, Vojtěch ADAM, Libuše TRNKOVÁ, Jaromír HUBÁLEK and René KIZEK. VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES. In \textit{XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků.}. Brno: Mendelova univerzita v Brně, 2012, p.~177-179. ISBN~978-80-7375-618-5.
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