HLA-G and HLA-E specific mRNAs connote opposite prognostic
significance in renal cell carcinoma

J 2012

HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma

KŘEN, Leoš, Ivo VALKOVSKÝ, Jan DOLEŽEL, Ivo ČAPÁK, Dalibor PACÍK et. al.

Basic information

Original name

HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma

Authors

KŘEN, Leoš (203 Czech Republic, guarantor, belonging to the institution), Ivo VALKOVSKÝ (203 Czech Republic), Jan DOLEŽEL (203 Czech Republic), Ivo ČAPÁK (203 Czech Republic), Dalibor PACÍK (203 Czech Republic, belonging to the institution), Alexandr POPRACH (203 Czech Republic), Radek LAKOMÝ (203 Czech Republic), Martina RÉDOVÁ (203 Czech Republic, belonging to the institution), Pavel FABIAN (203 Czech Republic), Zdenka KŘENOVÁ (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, belonging to the institution)

Edition

Diagnostic Pathology, LONDON, BIOMED CENTRAL LTD, 2012, 1746-1596

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.850

RIV identification code

RIV/00216224:14110/12:00060120

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/1746-1596-7-58

UT WoS

000306977900001

Keywords in English

renal cell carcinoma; radiotherapy; chemotherapy; HLA-G; HLA-E

Abstract

V originále

Background: Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods: In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results: We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT stage and lower nuclear Fuhrmann's grade. Conclusion: Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. Thus, these molecules could represent useful prognostic biomarkers in RCC, and the expression of both these molecules in RCC deserves further study. The virtual: Slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7383071387016614

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

KŘEN, Leoš, Ivo VALKOVSKÝ, Jan DOLEŽEL, Ivo ČAPÁK, Dalibor PACÍK, Alexandr POPRACH, Radek LAKOMÝ, Martina RÉDOVÁ, Pavel FABIAN, Zdenka KŘENOVÁ and Ondřej SLABÝ. HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma. Diagnostic Pathology. LONDON: BIOMED CENTRAL LTD, 2012, vol. 7, No 1, p. 58-64. ISSN 1746-1596. Available from: https://dx.doi.org/10.1186/1746-1596-7-58.

@article{984207,
   author = {Křen, Leoš and Valkovský, Ivo and Doležel, Jan and Čapák, Ivo and Pacík, Dalibor and Poprach, Alexandr and Lakomý, Radek and Rédová, Martina and Fabian, Pavel and Křenová, Zdenka and Slabý, Ondřej},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/1746-1596-7-58},
   keywords = {renal cell carcinoma; radiotherapy; chemotherapy; HLA-G; HLA-E},
   language = {eng},
   issn = {1746-1596},
   journal = {Diagnostic Pathology},
   title = {HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma},
   url = {http://www.diagnosticpathology.org/content/pdf/1746-1596-7-58.pdf},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 984207
AU  - Křen, Leoš - Valkovský, Ivo - Doležel, Jan - Čapák, Ivo - Pacík, Dalibor - Poprach, Alexandr - Lakomý, Radek - Rédová, Martina - Fabian, Pavel - Křenová, Zdenka - Slabý, Ondřej
PY  - 2012
TI  - HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma
JF  - Diagnostic Pathology
VL  - 7
IS  - 1
SP  - 58
EP  - 58
PB  - BIOMED CENTRAL LTD
SN  - 17461596
KW  - renal cell carcinoma
KW  - radiotherapy
KW  - chemotherapy
KW  - HLA-G
KW  - HLA-E
UR  - http://www.diagnosticpathology.org/content/pdf/1746-1596-7-58.pdf
N2  - Background: Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods: In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results: We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT stage and lower nuclear Fuhrmann's grade. Conclusion: Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. Thus, these molecules could represent useful prognostic biomarkers in RCC, and the expression of both these molecules in RCC deserves further study. The virtual: Slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7383071387016614
ER  -

KŘEN, Leoš, Ivo VALKOVSKÝ, Jan DOLEŽEL, Ivo ČAPÁK, Dalibor PACÍK, Alexandr POPRACH, Radek LAKOMÝ, Martina RÉDOVÁ, Pavel FABIAN, Zdenka KŘENOVÁ and Ondřej SLABÝ. HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma. \textit{Diagnostic Pathology}. LONDON: BIOMED CENTRAL LTD, 2012, vol.~7, No~1, p.~58-64. ISSN~1746-1596. Available from: https://dx.doi.org/10.1186/1746-1596-7-58.

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