CERNEI, Natalia Vladimirovna, Marketa KOMINKOVA, Ondřej ZÍTKA, Michal MASAŘÍK, Jaromír HUBÁLEK, Tomas ECKSCHLAGER, Libuše TRNKOVÁ, Vojtěch ADAM and René KIZEK. COULOMETRIC DETERMINATION OF SARCOSINE. In XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. Brno: Mendelova univerzita v Brně, 2012, p. 182-183. ISBN 978-80-7375-618-5.
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Basic information
Original name COULOMETRIC DETERMINATION OF SARCOSINE
Authors CERNEI, Natalia Vladimirovna (498 Republic of Moldova), Marketa KOMINKOVA (203 Czech Republic), Ondřej ZÍTKA (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic), Jaromír HUBÁLEK (203 Czech Republic), Tomas ECKSCHLAGER (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, belonging to the institution), Vojtěch ADAM (203 Czech Republic) and René KIZEK (203 Czech Republic, guarantor).
Edition Brno, XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. p. 182-183, 2 pp. 2012.
Publisher Mendelova univerzita v Brně
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10600 1.6 Biological sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14310/12:00060122
Organization unit Faculty of Science
ISBN 978-80-7375-618-5
Keywords in English sarcosine;N-methylglycine;glycine;prostate cancer;FIA-ED
Tags AKR, rivok
Changed by Changed by: Mgr. Sylvie Dohnalíková, učo 150911. Changed: 17/1/2013 09:06.
Abstract
Sarcosine, N-methylglycine, is a natural water soluble amino acid, which is a side product during the synthesis and degradation of glycine. Recently the hypothesis has been formulated that sarcosine can serve as a marker of prostate cancer and it is suitable for distinguishing of benign, localized and metastatic tumours. The aim of this work is to optimize the electrochemical coulometric detection coupled to flow injected analysis (FIA-ED). Limit of detection obtained by this method was 110 nM, which is sufficient for determination of sarcosine in various matrices including urine or blood of patients.
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