ŠOBROVÁ, Pavlína, Markéta RYVOLOVÁ, Libor JANŮ, Vojtěch ADAM, Libuše TRNKOVÁ, Jaromír HUBÁLEK and René KIZEK. QUANTUM DOTS AND THEIR INTERACTIONS WITH BIOMOLECULES. In XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. Brno: Mendelova univerzita v Brně, 2012, p. 237-238. ISBN 978-80-7375-618-5.
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Basic information
Original name QUANTUM DOTS AND THEIR INTERACTIONS WITH BIOMOLECULES
Authors ŠOBROVÁ, Pavlína (203 Czech Republic), Markéta RYVOLOVÁ (203 Czech Republic), Libor JANŮ (203 Czech Republic), Vojtěch ADAM (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, belonging to the institution), Jaromír HUBÁLEK (203 Czech Republic) and René KIZEK (203 Czech Republic, guarantor).
Edition Brno, XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. p. 237-238, 2 pp. 2012.
Publisher Mendelova univerzita v Brně
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10600 1.6 Biological sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14310/12:00060130
Organization unit Faculty of Science
ISBN 978-80-7375-618-5
Keywords in English quantum dots;oligonucleotides;differential pulse voltammetry;prion protein
Tags AKR, rivok
Changed by Changed by: Mgr. Sylvie Dohnalíková, učo 150911. Changed: 17/1/2013 09:15.
Abstract
Semiconductor quantum dots (QDs) coated with thioalkyl acid ligands are often used as probes and reporters for nucleic acid sensing, or protein sensing using aptamers, and are also potential vectors for gene delivery. In such applications, the interactions that potentially lead to the adsorption of oligonucleotides onto the surface of colloidal QDs are an important consideration. The interaction between Beta-sheet breaker prion protein and CdTe quantum dots (QDs) was studied by differential pulse voltammetry connected with adsorptive transfer stripping technique. Results showed that the electrochemical signals of prion protein were strongly quenched by CdTe QDs. This phenomenon can be considered as a first step of suggesting of a biosensor for determination of prions in real samples without a sample pre-treatment.
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