ŠÁNA, Jiří, Simona HANKEOVÁ, Marek SVOBODA, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer. Oncology. Basel: Karger, 2012, vol. 82, No 2, p. 114-118. ISSN 0030-2414. Available from: https://dx.doi.org/10.1159/000336479.
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Basic information
Original name Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer
Authors ŠÁNA, Jiří (203 Czech Republic, belonging to the institution), Simona HANKEOVÁ (203 Czech Republic), Marek SVOBODA (203 Czech Republic), Igor KISS (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
Edition Oncology, Basel, Karger, 2012, 0030-2414.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.165
RIV identification code RIV/00216224:14740/12:00060135
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1159/000336479
UT WoS 000301774000007
Keywords in English Colorectal cancer; Non-coding RNAs; Transcribed ultraconserved regions; uc.73; uc.388
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 10/4/2013 17:57.
Abstract
The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequenc es longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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