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@inproceedings{984272,
author = {Knopfová, Lucia and Beneš, Petr and Pekarčíková, Lucie and Hermanová, Markéta and Masařík, Michal and Šmarda, Jan},
address = {Cavtat, Dubrovnik},
booktitle = {Cellular Signaling and Molecular Medicine},
editor = {EMBO},
keywords = {myb breast carcinoma metastasis organotropism},
language = {eng},
location = {Cavtat, Dubrovnik},
pages = {131-131},
publisher = {EMBO},
title = {Regulation of cathepsin D and MMP1/9 by c-Myb is a novel mechanism of the matrix-specific breast cancer cell invasion},
year = {2012}
}
TY - JOUR
ID - 984272
AU - Knopfová, Lucia - Beneš, Petr - Pekarčíková, Lucie - Hermanová, Markéta - Masařík, Michal - Šmarda, Jan
PY - 2012
TI - Regulation of cathepsin D and MMP1/9 by c-Myb is a novel mechanism of the matrix-specific breast cancer cell invasion
PB - EMBO
CY - Cavtat, Dubrovnik
KW - myb breast carcinoma metastasis organotropism
N2 - There are conflicting results concerning the c-Myb function in breast cancer. Both oncogenic and tumor-suppressing effects of c-Myb in breast cancer have been recently described. The aim of this study is to elucidate a specific role of c-Myb in control of breast cancer cell invasion. We report that ectopically expressed c-Myb enhances migration of human MDA-MB-231 and mouse 4T1 mammary cancer cells and their ability to invade Matrigel but not the collagen I matrix in vitro. Invasive behavior of breast cancer cells in vivo was determined in a syngeneic mouse mammary tumor model using 4T1 cells. c-myb overexpression in 4T1 cells injected into the mammary fat pads delayed the growth of mammary tumors in BALB/c mice and affected the metastatic potential of breast cancer cells in an organ-specific manner. c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 (92-kDa gelatinase) and significantly downregulated MMP1 (interstitial collagenase). Differential expression of these specific proteases induced by c-Myb was suggested as a mechanism of matrix-specific cell invasion. This study identified c-Myb as a matrix-dependent modifier of invasive breast tumor cell functions. These findings provide new clues for understanding of the oncogenic/tumor-suppressing functions of c-Myb.
ER -
KNOPFOVÁ, Lucia, Petr BENEŠ, Lucie PEKARČÍKOVÁ, Markéta HERMANOVÁ, Michal MASAŘÍK a Jan ŠMARDA. Regulation of cathepsin D and MMP1/9 by c-Myb is a novel mechanism of the matrix-specific breast cancer cell invasion. In EMBO. \textit{Cellular Signaling and Molecular Medicine}. Cavtat, Dubrovnik: EMBO. s.~131. 2012.
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