Nestin expression in high-grade osteosarcomas and its clinical
significance

J 2012

Nestin expression in high-grade osteosarcomas and its clinical significance

ZAMBO, Iva, Markéta HERMANOVÁ, Dagmar ADÁMKOVÁ KRÁKOROVÁ, Peter MÚDRY, Karel ZITTERBART et. al.

Basic information

Original name

Nestin expression in high-grade osteosarcomas and its clinical significance

Authors

ZAMBO, Iva (203 Czech Republic, guarantor, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Dagmar ADÁMKOVÁ KRÁKOROVÁ (203 Czech Republic, belonging to the institution), Peter MÚDRY (203 Czech Republic, belonging to the institution), Karel ZITTERBART (203 Czech Republic, belonging to the institution), Michal KÝR (203 Czech Republic, belonging to the institution), Karel VESELÝ (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution) and Renata VESELSKÁ (203 Czech Republic, belonging to the institution)

Edition

Oncology Reports, Athens, Greece, Spandidos Publications Ltd. 2012, 1021-335X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.297

RIV identification code

RIV/00216224:14110/12:00060164

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3892/or.2012.1687

UT WoS

000302202600044

Keywords (in Czech)

osteosarkom; nestin; prognóza; imunohistochemie; imunofluorescence

Keywords in English

osteosarcoma; nestin; prognosis; immunohistochemistry; immunofluorescence

Abstract

V originále

Using immunohistochemistry and immunofluorescence, we evaluated nestin expression in tumor tissue samples from 45 patients with high-grade osteosarcomas. High levels of nestin expression detected by immunofluorescence were associated with worse clinical outcomes. However, high levels of nestin expression detected by immunohistochemistry trended towards shorter OS and EFS but did not reach statistical significance. Nestin does not seem to represent a powerful prognostic marker for patients with high-grade osteosarcomas.

Links

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

Files attached

Oncol_Rep_Early_Online_or_2012_1687.pdf

Request the author's version of the file

Citovat

ZAMBO, Iva, Markéta HERMANOVÁ, Dagmar ADÁMKOVÁ KRÁKOROVÁ, Peter MÚDRY, Karel ZITTERBART, Michal KÝR, Karel VESELÝ, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Nestin expression in high-grade osteosarcomas and its clinical significance. Oncology Reports. Athens, Greece: Spandidos Publications Ltd., 2012, vol. 27, No 5, p. 1592-1598. ISSN 1021-335X. Available from: https://dx.doi.org/10.3892/or.2012.1687.

@article{984770,
   author = {Zambo, Iva and Hermanová, Markéta and Adámková Krákorová, Dagmar and Múdry, Peter and Zitterbart, Karel and Kýr, Michal and Veselý, Karel and Štěrba, Jaroslav and Veselská, Renata},
   article_location = {Athens, Greece},
   article_number = {5},
   doi = {http://dx.doi.org/10.3892/or.2012.1687},
   keywords = {osteosarcoma; nestin; prognosis; immunohistochemistry; immunofluorescence},
   language = {eng},
   issn = {1021-335X},
   journal = {Oncology Reports},
   title = {Nestin expression in high-grade osteosarcomas and its clinical significance},
   volume = {27},
   year = {2012}
}

TY  - JOUR
ID  - 984770
AU  - Zambo, Iva - Hermanová, Markéta - Adámková Krákorová, Dagmar - Múdry, Peter - Zitterbart, Karel - Kýr, Michal - Veselý, Karel - Štěrba, Jaroslav - Veselská, Renata
PY  - 2012
TI  - Nestin expression in high-grade osteosarcomas and its clinical significance
JF  - Oncology Reports
VL  - 27
IS  - 5
SP  - 1592-1598
EP  - 1592-1598
PB  - Spandidos Publications Ltd.
SN  - 1021335X
KW  - osteosarcoma
KW  - nestin
KW  - prognosis
KW  - immunohistochemistry
KW  - immunofluorescence
N2  - Using immunohistochemistry and immunofluorescence, we evaluated nestin expression in tumor tissue samples from 45 patients with high-grade osteosarcomas. High levels of nestin expression detected by immunofluorescence were associated with worse clinical outcomes. However, high levels of nestin expression detected by immunohistochemistry trended towards shorter OS and EFS but did not reach statistical significance. Nestin does not seem to represent a powerful prognostic marker for patients with high-grade osteosarcomas.
ER  -

ZAMBO, Iva, Markéta HERMANOVÁ, Dagmar ADÁMKOVÁ KRÁKOROVÁ, Peter MÚDRY, Karel ZITTERBART, Michal KÝR, Karel VESELÝ, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Nestin expression in high-grade osteosarcomas and its clinical significance. \textit{Oncology Reports}. Athens, Greece: Spandidos Publications Ltd., 2012, vol.~27, No~5, p.~1592-1598. ISSN~1021-335X. Available from: https://dx.doi.org/10.3892/or.2012.1687.

Detailed Information on Publication Record