SLABÝ, Ondřej. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, 192 pp. ISBN 978-1-61324-514-9.
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Basic information
Original name MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets
Authors SLABÝ, Ondřej.
Edition New York, 192 pp. 2012.
Publisher Nova Science Publishers, Inc.
Other information
Original language English
Type of outcome Book on a specialized topic
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
Organization unit Central European Institute of Technology
ISBN 978-1-61324-514-9
Keywords in English microRNAs; solid cancer; biomarkers; therapeutic targets
Tags poznámka
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 15/4/2016 08:29.
Abstract
MiRNA is extremely fast growing field, and miRNA knowledge is now believed to be a pivotal element of cancer biology. An individual miRNA interferes with a broad range of mRNAs; conversely, a single mRNA could be targeted by a variety of miRNAs. The complexity of miRNA:mRNA interaction is far-reaching and a bit beyond our understanding to date. It is already evident that the discovery of miRNA has created a paradigm shift in post-genomics biology, not only for scientists accustomed to traditional central dogma of molecular biology but also for researchers studying human diseases and accustomed to traditional genetics approach of studying one gene at the time. The ability of miRNAs to control large groups of genes and impose global post-transcriptional regulation of many (if not all) important cellular processes in development, cell proliferation and differentiation has opened up a new dimension and uncovered complexity of intracellular regulatory processes. This book is expected to provide introduction to the basic principles of miRNA biology, overview of miRNA significance in the hallmarks of cancer, experimental techniques used in miRNA research, and in special part - miRNAs importance in wide range of solid cancers with a special focus on its potential usage in molecular pathology, predictive oncology or as a novel therapeutic targets.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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