MicroRNAs Biogenesis, Function and Decay

SLABÝ, Ondřej and Jiří ŠÁNA. MicroRNAs Biogenesis, Function and Decay. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 1-20. ISBN 978-1-61324-514-9.

Basic information

Original name

MicroRNAs Biogenesis, Function and Decay

Authors

SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution) and Jiří ŠÁNA (203 Czech Republic, belonging to the institution)

Edition

New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 1-20, 20 pp. 2012

Publisher

Nova Science Publishers, Inc.

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Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14740/12:00060169

Organization unit

Central European Institute of Technology

ISBN

978-1-61324-514-9

Keywords in English

microRNAs; biogenesis; function; decay

Tags

ok, rivok

Tags

International impact, Reviewed

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Abstract

V originále

MicroRNAs (miRNAs) are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. Recent studies, however, have introduced a paradigm shift in our understanding of the miRNA biogenesis pathway, which was previously believed to be universal to all miRNAs. It has become apparent that miRNA regulators themselves are subject to sophisticated control, which takes place at the levels of both miRNA metabolism and function. In this chapter we focus on the recent advances in knowledge of the miRNA biogenesis pathways and regulatory mechanisms involved in miRNA gene transcription, processing, maturation and functionality. Potential impact of the alterations in miRNA biogenesis pathways on cancer pathogenesis is discussed.

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Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology