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@inbook{984807,
author = {Slabý, Ondřej and Šána, Jiří},
address = {New York},
booktitle = {MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets},
editor = {Ondrej Slaby},
keywords = {microRNAs; biogenesis; function; decay},
howpublished = {tištěná verze "print"},
language = {eng},
location = {New York},
isbn = {978-1-61324-514-9},
pages = {1-20},
publisher = {Nova Science Publishers, Inc.},
title = {MicroRNAs Biogenesis, Function and Decay},
year = {2012}
}
TY - CHAP
ID - 984807
AU - Slabý, Ondřej - Šána, Jiří
PY - 2012
TI - MicroRNAs Biogenesis, Function and Decay
VL - Neuveden
PB - Nova Science Publishers, Inc.
CY - New York
SN - 9781613245149
KW - microRNAs
KW - biogenesis
KW - function
KW - decay
N2 - MicroRNAs (miRNAs) are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. Recent studies, however, have introduced a paradigm shift in our understanding of the miRNA biogenesis pathway, which was previously believed to be universal to all miRNAs. It has become apparent that miRNA regulators themselves are subject to sophisticated control, which takes place at the levels of both miRNA metabolism and function. In this chapter we focus on the recent advances in knowledge of the miRNA biogenesis pathways and regulatory mechanisms involved in miRNA gene transcription, processing, maturation and functionality. Potential impact of the alterations in miRNA biogenesis pathways on cancer pathogenesis is discussed.
ER -
SLABÝ, Ondřej and Jiří ŠÁNA. MicroRNAs Biogenesis, Function and Decay. In Ondrej Slaby. \textit{MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets}. New York: Nova Science Publishers, Inc., 2012, p.~1-20. ISBN~978-1-61324-514-9.
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