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@inbook{984818,
author = {Slabý, Ondřej},
address = {New York},
booktitle = {MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets},
editor = {Ondrej Slaby},
keywords = {microRNAs; cancer; genetic polymorphisms},
howpublished = {tištěná verze "print"},
language = {eng},
location = {New York},
isbn = {978-1-61324-514-9},
pages = {21-28},
publisher = {Nova Science Publishers, Inc.},
title = {MicroRNAs and Genetic Polymorphisms in Cancer},
year = {2012}
}
TY - CHAP
ID - 984818
AU - Slabý, Ondřej
PY - 2012
TI - MicroRNAs and Genetic Polymorphisms in Cancer
VL - Neuveden
PB - Nova Science Publishers, Inc.
CY - New York
SN - 9781613245149
KW - microRNAs
KW - cancer
KW - genetic polymorphisms
N2 - Single nucleotide polymorphisms (SNPs) may occur at the level of miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or the mature miRNA sequence. Such SNPs may be functional in the biogenesis and action of the mature miRNA. SNPs located to predicted miRNA target sites within 3' UTR of mRNAs have the potential to affect the efficiency of miRNA binding on its target site, create or destroy binding sites. Resulting gene deregulation can involve changes in phenotype and be eventually critical not only for the susceptibility and the onset of cancer, but also for its prognosis and therapy response prediction.
ER -
SLABÝ, Ondřej. MicroRNAs and Genetic Polymorphisms in Cancer. In Ondrej Slaby. \textit{MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets}. New York: Nova Science Publishers, Inc., 2012, s.~21-28. ISBN~978-1-61324-514-9.
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