MicroRNAs and Genetic Polymorphisms in Cancer

SLABÝ, Ondřej. MicroRNAs and Genetic Polymorphisms in Cancer. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 21-28. ISBN 978-1-61324-514-9.

Basic information

Original name

MicroRNAs and Genetic Polymorphisms in Cancer

Authors

SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution)

Edition

New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 21-28, 8 pp. 2012

Publisher

Nova Science Publishers, Inc.

---

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14740/12:00060174

Organization unit

Central European Institute of Technology

ISBN

978-1-61324-514-9

Keywords in English

microRNAs; cancer; genetic polymorphisms

Tags

ok, rivok

Tags

International impact, Reviewed

---

Abstract

V originále

Single nucleotide polymorphisms (SNPs) may occur at the level of miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or the mature miRNA sequence. Such SNPs may be functional in the biogenesis and action of the mature miRNA. SNPs located to predicted miRNA target sites within 3' UTR of mRNAs have the potential to affect the efficiency of miRNA binding on its target site, create or destroy binding sites. Resulting gene deregulation can involve changes in phenotype and be eventually critical not only for the susceptibility and the onset of cancer, but also for its prognosis and therapy response prediction.

---

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology