SLABÝ, Ondřej. MicroRNAs and the Hallmarks of Cancer. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 47-64. ISBN 978-1-61324-514-9.
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Basic information
Original name MicroRNAs and the Hallmarks of Cancer
Authors SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution).
Edition New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 47-64, 18 pp. 2012.
Publisher Nova Science Publishers, Inc.
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14740/12:00060175
Organization unit Central European Institute of Technology
ISBN 978-1-61324-514-9
Keywords in English microRNAs; cancer; hallmarks
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 13/3/2013 13:35.
Abstract
A growing amount of evidences proves that microRNAs (miRNAs) can work as oncogenes (activating the malignant potential) or tumor suppressor genes (blocking the malignant potential) and they can affect all of the six hallmarks of cancer defined by Hanahan and Weinberg (2000) as: self-sufficiency in growth signals, insensitivity to growth inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis and tissue invasion and metastasis. In this chapter we focus on miRNAs significance in these various aspects of cancer biology.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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