MicroRNAs and the Hallmarks of Cancer

SLABÝ, Ondřej. MicroRNAs and the Hallmarks of Cancer. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 47-64. ISBN 978-1-61324-514-9.

Basic information

Original name

MicroRNAs and the Hallmarks of Cancer

Authors

SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution)

Edition

New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 47-64, 18 pp. 2012

Publisher

Nova Science Publishers, Inc.

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Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14740/12:00060175

Organization unit

Central European Institute of Technology

ISBN

978-1-61324-514-9

Keywords in English

microRNAs; cancer; hallmarks

Tags

ok, rivok

Tags

International impact, Reviewed

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Abstract

V originále

A growing amount of evidences proves that microRNAs (miRNAs) can work as oncogenes (activating the malignant potential) or tumor suppressor genes (blocking the malignant potential) and they can affect all of the six hallmarks of cancer defined by Hanahan and Weinberg (2000) as: self-sufficiency in growth signals, insensitivity to growth inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis and tissue invasion and metastasis. In this chapter we focus on miRNAs significance in these various aspects of cancer biology.

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Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology