SLABÝ, Ondřej. MicroRNAs and Gastric Cancer. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 149-160. ISBN 978-1-61324-514-9.
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Basic information
Original name MicroRNAs and Gastric Cancer
Authors SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution).
Edition New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 149-160, 12 pp. 2012.
Publisher Nova Science Publishers, Inc.
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14740/12:00060176
Organization unit Central European Institute of Technology
ISBN 978-1-61324-514-9
Keywords in English microRNAs; gastric cancer
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 19/3/2013 09:06.
Abstract
Gastric cancer is the fourth most common cancer in the world. Polymorphisms within miRNA genes have been described as new risk factors for atrophic gastritis and gastric cancer. A substantial number of miRNAs show differential expression in gastric cancer tissues. Genes coding for these miRNAs have been characterized as novel protooncogenes and tumor-suppressor genes based on findings that these miRNAs control malignant phenotypes of gastric cancer cells and the carcinogenic effect of Helicobacter pylori infection. Several investigations have also described the ability of specific miRNA expression profiles to predict prognosis, and potential of selected miRNAs as therapeutic targets in gastric cancer patients.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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