ŠÁNA, Jiří, Marian HAJDÚCH and Ondřej SLABÝ. MicroRNA and Glial Tumors: Tiny Relation with Great Potential. In Prof. Faris Farassati. Novel Therapeutic Concepts in Targeting Glioma. Neuveden: InTech, 2012, p. 59-74. ISBN 978-953-51-0491-9. Available from: https://dx.doi.org/10.5772/22941.
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Basic information
Original name MicroRNA and Glial Tumors: Tiny Relation with Great Potential
Authors ŠÁNA, Jiří (203 Czech Republic, guarantor, belonging to the institution), Marian HAJDÚCH (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, belonging to the institution).
Edition Neuveden, Novel Therapeutic Concepts in Targeting Glioma, p. 59-74, 16 pp. 2012.
Publisher InTech
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30200 3.2 Clinical medicine
Country of publisher Croatia
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
WWW URL URL
RIV identification code RIV/00216224:14740/12:00060177
Organization unit Central European Institute of Technology
ISBN 978-953-51-0491-9
Doi http://dx.doi.org/10.5772/22941
Keywords in English microRNAs; glial tumors
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 10/4/2013 00:43.
Abstract
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was many times showed that miRNAs are involved in core signaling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs have a great potential for oncodiagnostic as well as could be promising therapeutic targets in gliomas.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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