Cyclin K goes with Cdk12 and Cdk13

J 2012

Cyclin K goes with Cdk12 and Cdk13

KOHOUTEK, Jiří and Dalibor BLAŽEK

Basic information

Original name

Cyclin K goes with Cdk12 and Cdk13

Authors

KOHOUTEK, Jiří (203 Czech Republic) and Dalibor BLAŽEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cell Division, London, Biomed Central Ltd. 2012, 1747-1028

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.471

RIV identification code

RIV/00216224:14740/12:00057443

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1186/1747-1028-7-12

UT WoS

000303827600001

Keywords in English

Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2

Abstract

V originále

The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins’ functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP305/11/1564, research and development project

Name: Nová izoforma cyklinu K je partnerem kinázy cdk12 regulující transkripci a alternativní sestřih u eukaryot

Investor: Czech Science Foundation

SRGA454, interní kód MU

Name: Regulace a funkce P-TEFb komplexů (Acronym: P-TEFb)

Investor: South-Moravian Region, Incoming grants

Citovat

KOHOUTEK, Jiří and Dalibor BLAŽEK. Cyclin K goes with Cdk12 and Cdk13. Cell Division. London: Biomed Central Ltd., 2012, vol. 7, No 12, p. "nestránkováno", 10 pp. ISSN 1747-1028. Available from: https://dx.doi.org/10.1186/1747-1028-7-12.

@article{984838,
   author = {Kohoutek, Jiří and Blažek, Dalibor},
   article_location = {London},
   article_number = {12},
   doi = {http://dx.doi.org/10.1186/1747-1028-7-12},
   keywords = {Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2},
   language = {eng},
   issn = {1747-1028},
   journal = {Cell Division},
   title = {Cyclin K goes with Cdk12 and Cdk13},
   url = {http://www.celldiv.com/content/7/1/12},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 984838
AU  - Kohoutek, Jiří - Blažek, Dalibor
PY  - 2012
TI  - Cyclin K goes with Cdk12 and Cdk13
JF  - Cell Division
VL  - 7
IS  - 12
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Biomed Central Ltd.
SN  - 17471028
KW  - Transcription
KW  - Posttranscriptional processing
KW  - DNA damage
KW  - P-TEFb
KW  - Cyclin L
KW  - CTD code
KW  - CTD kinase
KW  - Phosphorylation of serine 2
KW  - BRCA1
KW  - ATR
KW  - FANCI
KW  - FANCD2
UR  - http://www.celldiv.com/content/7/1/12
L2  - http://www.celldiv.com/content/7/1/12
N2  - The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins’ functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.
ER  -

KOHOUTEK, Jiří and Dalibor BLAŽEK. Cyclin K goes with Cdk12 and Cdk13. \textit{Cell Division}. London: Biomed Central Ltd., 2012, vol.~7, No~12, p.~''nestránkováno'', 10 pp. ISSN~1747-1028. Available from: https://dx.doi.org/10.1186/1747-1028-7-12.

Detailed Information on Publication Record