Cyclin K goes with Cdk12 and Cdk13

KOHOUTEK, Jiří and Dalibor BLAŽEK. Cyclin K goes with Cdk12 and Cdk13. Cell Division. London: Biomed Central Ltd., 2012, vol. 7, No 12, p. "nestránkováno", 10 pp. ISSN 1747-1028. Available from: https://dx.doi.org/10.1186/1747-1028-7-12.

Basic information

• Original name: Cyclin K goes with Cdk12 and Cdk13
• Authors: KOHOUTEK, Jiří (203 Czech Republic) and Dalibor BLAŽEK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Cell Division, London, Biomed Central Ltd. 2012, 1747-1028.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.471
• RIV identification code: RIV/00216224:14740/12:00057443
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1186/1747-1028-7-12
• UT WoS: 000303827600001
• Keywords in English: Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins’ functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GAP305/11/1564, research and development project: Name: Nová izoforma cyklinu K je partnerem kinázy cdk12 regulující transkripci a alternativní sestřih u eukaryot

Investor: Czech Science Foundation

• SRGA454, interní kód MU: Name: Regulace a funkce P-TEFb komplexů (Acronym: P-TEFb)

Investor: South-Moravian Region, Incoming grants