| ŠÁNA, Jiří, Simona HANKEOVÁ, Radek LAKOMÝ, Ondřej SLABÝ, Eva LŽIČAŘOVÁ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Rostislav VYZULA and Jaroslav MICHÁLEK. MiRNA-181b and miRNA-181c expression levels may predict survival and response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. In The 16th Annual Meeting of the RNA Society and The 13th Annual Meeting of the RNA Society of Japan, RNA 2011, Kyoto, Japan. 2011. |
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@proceedings{984894,
author = {Šána, Jiří and Hankeová, Simona and Lakomý, Radek and Slabý, Ondřej and Lžičařová, Eva and Křen, Leoš and Fadrus, Pavel and Smrčka, Martin and Vyzula, Rostislav and Michálek, Jaroslav},
booktitle = {The 16th Annual Meeting of the RNA Society and The 13th Annual Meeting of the RNA Society of Japan, RNA 2011, Kyoto, Japan},
keywords = {microRNA; concomitant chemoradiotherapy; temozolomide; glioblastoma multiforme},
title = {MiRNA-181b and miRNA-181c expression levels may predict survival and response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients.},
year = {2011}
}
TY - CONF
ID - 984894
AU - Šána, Jiří - Hankeová, Simona - Lakomý, Radek - Slabý, Ondřej - Lžičařová, Eva - Křen, Leoš - Fadrus, Pavel - Smrčka, Martin - Vyzula, Rostislav - Michálek, Jaroslav
PY - 2011
TI - MiRNA-181b and miRNA-181c expression levels may predict survival and response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients.
KW - microRNA
KW - concomitant chemoradiotherapy
KW - temozolomide
KW - glioblastoma multiforme
N2 - Glioblastoma multiforme (GBM) is the most lethal primary brain tumor and is characterized by a poor prognosis, resistance to standard therapies, and a highly mutated tumor genome. It is therefore critical to identify new molecular targets that contribute to GBM pathogenesis in order to develop novel targeted therapeutic and diagnostic strategies. MicroRNAs (miRNAs) represent an emerging class of molecules that play significant roles in a number of key cellular processes associated with GBM. This review summarizes the results of recent studies that have attempted to profile the miRNA expression signatures of GBM. Additionally, this review highlights the downstream effectors and activities of key oncogenic or tumor suppressive miRNAs in GBM and describes some promising therapeutic, diagnostic, and prognostic strategies involving miRNAs.
ER -
ŠÁNA, Jiří, Simona HANKEOVÁ, Radek LAKOMÝ, Ondřej SLABÝ, Eva LŽIČAŘOVÁ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Rostislav VYZULA and Jaroslav MICHÁLEK. MiRNA-181b and miRNA-181c expression levels may predict survival and response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. In \textit{The 16th Annual Meeting of the RNA Society and The 13th Annual Meeting of the RNA Society of Japan, RNA 2011, Kyoto, Japan}. 2011.
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