Informační systém MU
HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Martina RÉDOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer. World Journal of Gastroenterology. Beijing, China: Baishideng, 2012, vol. 18, No 22, p. 2827-2831. ISSN 1007-9327. Available from: https://dx.doi.org/10.3748/wjg.v18.i22.2827.
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Basic information
Original name Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
Authors HÉŽOVÁ, Renata (203 Czech Republic), Alena KOVAŘÍKOVÁ (203 Czech Republic), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Milana ŠACHLOVÁ (203 Czech Republic), Martina RÉDOVÁ (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic), Lenka RADOVÁ (203 Czech Republic), Igor KISS (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
Edition World Journal of Gastroenterology, Beijing, China, Baishideng, 2012, 1007-9327.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher China
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.547
RIV identification code RIV/00216224:14740/12:00060270
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.3748/wjg.v18.i22.2827
UT WoS 000305445200012
Keywords in English Association study; Colorectal cancer; MicroRNA; Single nucleotide polymorphism
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 10/4/2013 13:27.
Abstract
In order to investigate the effect of selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.The genotype and allele frequencies of SNPs were compared between the cases and the controls. Unfortunately, none of the performed analysis showed any statistically significant results. Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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