Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk
factors of colorectal cancer

J 2012

Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Martina RÉDOVÁ et. al.

Basic information

Original name

Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

Authors

HÉŽOVÁ, Renata (203 Czech Republic), Alena KOVAŘÍKOVÁ (203 Czech Republic), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Milana ŠACHLOVÁ (203 Czech Republic), Martina RÉDOVÁ (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic), Lenka RADOVÁ (203 Czech Republic), Igor KISS (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

World Journal of Gastroenterology, Beijing, China, Baishideng, 2012, 1007-9327

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

China

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.547

RIV identification code

RIV/00216224:14740/12:00060270

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3748/wjg.v18.i22.2827

UT WoS

000305445200012

Keywords in English

Association study; Colorectal cancer; MicroRNA; Single nucleotide polymorphism

Abstract

V originále

In order to investigate the effect of selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.The genotype and allele frequencies of SNPs were compared between the cases and the controls. Unfortunately, none of the performed analysis showed any statistically significant results. Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Martina RÉDOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer. World Journal of Gastroenterology. Beijing, China: Baishideng, 2012, vol. 18, No 22, p. 2827-2831. ISSN 1007-9327. Available from: https://dx.doi.org/10.3748/wjg.v18.i22.2827.

@article{985898,
   author = {Héžová, Renata and Kovaříková, Alena and Bienertová Vašků, Julie and Šachlová, Milana and Rédová, Martina and Vašků, Anna and Svoboda, Marek and Radová, Lenka and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {Beijing, China},
   article_number = {22},
   doi = {http://dx.doi.org/10.3748/wjg.v18.i22.2827},
   keywords = {Association study; Colorectal cancer; MicroRNA; Single nucleotide polymorphism},
   language = {eng},
   issn = {1007-9327},
   journal = {World Journal of Gastroenterology},
   title = {Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer},
   url = {http://www.wjgnet.com/1007-9327/full/v18/i22/2827.htm},
   volume = {18},
   year = {2012}
}

TY  - JOUR
ID  - 985898
AU  - Héžová, Renata - Kovaříková, Alena - Bienertová Vašků, Julie - Šachlová, Milana - Rédová, Martina - Vašků, Anna - Svoboda, Marek - Radová, Lenka - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
JF  - World Journal of Gastroenterology
VL  - 18
IS  - 22
SP  - 2827-2831
EP  - 2827-2831
PB  - Baishideng
SN  - 10079327
KW  - Association study
KW  - Colorectal cancer
KW  - MicroRNA
KW  - Single nucleotide polymorphism
UR  - http://www.wjgnet.com/1007-9327/full/v18/i22/2827.htm
L2  - http://www.wjgnet.com/1007-9327/full/v18/i22/2827.htm
N2  - In order to investigate the effect of selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.The genotype and allele frequencies of SNPs were compared between the cases and the controls. Unfortunately, none of the performed analysis showed any statistically significant results. Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer.
ER  -

HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Martina RÉDOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer. \textit{World Journal of Gastroenterology}. Beijing, China: Baishideng, 2012, vol.~18, No~22, p.~2827-2831. ISSN~1007-9327. Available from: https://dx.doi.org/10.3748/wjg.v18.i22.2827.

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