Electrochemical Study of Doxorubicin Interaction with Different
Sequences of Double Stranded Oligonucleotides, Part II

J 2012

Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II

HYNEK, David, Ludmila KREJČOVÁ, Ondřej ZÍTKA, Vojtěch ADAM, Libuše TRNKOVÁ et. al.

Basic information

Original name

Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II

Authors

HYNEK, David (203 Czech Republic), Ludmila KREJČOVÁ (203 Czech Republic), Ondřej ZÍTKA (203 Czech Republic), Vojtěch ADAM (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, belonging to the institution), Jiří SOCHOR (203 Czech Republic), Marie STIBOROVÁ (203 Czech Republic), Tomáš ECKSCHLAGER (203 Czech Republic), Jaromír HUBÁLEK (203 Czech Republic) and René KIZEK (203 Czech Republic, guarantor)

Edition

International Journal of Electrochemical Science, 2012, 1452-3981

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10403 Physical chemistry

Country of publisher

Serbia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.729 in 2011

RIV identification code

RIV/00216224:14310/12:00060307

Organization unit

Faculty of Science

UT WoS

000302723700003

Keywords in English

intercalating drug; doxorubicin; hetero-nucleotides; square wave voltammetry; adsorptive transfer stripping technique; adriamycin; DNA

Abstract

V originále

Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hynek et al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations of doxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure.

Citovat

HYNEK, David, Ludmila KREJČOVÁ, Ondřej ZÍTKA, Vojtěch ADAM, Libuše TRNKOVÁ, Jiří SOCHOR, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Jaromír HUBÁLEK and René KIZEK. Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II. International Journal of Electrochemical Science. 2012, vol. 7, No 1, p. 34-49. ISSN 1452-3981.

@article{986085,
   author = {Hynek, David and Krejčová, Ludmila and Zítka, Ondřej and Adam, Vojtěch and Trnková, Libuše and Sochor, Jiří and Stiborová, Marie and Eckschlager, Tomáš and Hubálek, Jaromír and Kizek, René},
   article_number = {1},
   keywords = {intercalating drug; doxorubicin; hetero-nucleotides; square wave voltammetry; adsorptive transfer stripping technique; adriamycin; DNA},
   language = {eng},
   issn = {1452-3981},
   journal = {International Journal of Electrochemical Science},
   title = {Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 986085
AU  - Hynek, David - Krejčová, Ludmila - Zítka, Ondřej - Adam, Vojtěch - Trnková, Libuše - Sochor, Jiří - Stiborová, Marie - Eckschlager, Tomáš - Hubálek, Jaromír - Kizek, René
PY  - 2012
TI  - Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II
JF  - International Journal of Electrochemical Science
VL  - 7
IS  - 1
SP  - 34-49
EP  - 34-49
SN  - 14523981
KW  - intercalating drug
KW  - doxorubicin
KW  - hetero-nucleotides
KW  - square wave voltammetry
KW  - adsorptive transfer stripping technique
KW  - adriamycin
KW  - DNA
N2  - Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hynek et al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations of doxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure.
ER  -

HYNEK, David, Ludmila KREJČOVÁ, Ondřej ZÍTKA, Vojtěch ADAM, Libuše TRNKOVÁ, Jiří SOCHOR, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Jaromír HUBÁLEK and René KIZEK. Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II. \textit{International Journal of Electrochemical Science}. 2012, vol.~7, No~1, p.~34-49. ISSN~1452-3981.

Detailed Information on Publication Record