J
2012
Biocompatible Xanthine-Quadruplex Scaffold for Ion-Transporting DNA Channels
NOVOTNÝ, Jan, Petr KULHÁNEK and Radek MAREK
Basic information
Original name
Biocompatible Xanthine-Quadruplex Scaffold for Ion-Transporting DNA Channels
Authors
NOVOTNÝ, Jan (203 Czech Republic, belonging to the institution),
Petr KULHÁNEK (203 Czech Republic, belonging to the institution) and
Radek MAREK (203 Czech Republic, guarantor, belonging to the institution)
Edition
The Journal of Physical Chemistry Letters, Washington, American Chemical Society, 2012, 1948-7185
Other information
Type of outcome
Článek v odborném periodiku
Field of Study
10403 Physical chemistry
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 6.585
RIV identification code
RIV/00216224:14740/12:00060331
Organization unit
Central European Institute of Technology
Keywords (in Czech)
molekulová dynamika; guanin; potenciál střední síly; přenos iontu; volná energie
Keywords in English
molecular dynamics; guanine; adaptive biasing force; ion transport; free-energy
Tags
International impact, Reviewed
V originále
Molecular dynamics simulations and adaptive biasing force analysis of the quadruplex DNA dynamics in an explicit solvent reveal fundamentally different mechanisms of Na+ transport in xanthine- and guanine-based DNA systems. The barrier to the transport of K+ through the xanthine-based quadruplex is significantly lower than those reported for the guanine-based analogs.
Links
| ED1.1.00/02.0068, research and development project | | Name: CEITEC - central european institute of technology |
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