NOVOTNÝ, Jan, Petr KULHÁNEK and Radek MAREK. Biocompatible Xanthine-Quadruplex Scaffold for Ion-Transporting DNA Channels. The Journal of Physical Chemistry Letters. Washington: American Chemical Society, 2012, vol. 3, No 13, p. 1788-1792. ISSN 1948-7185. Available from: https://dx.doi.org/10.1021/jz300559w.
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Basic information
Original name Biocompatible Xanthine-Quadruplex Scaffold for Ion-Transporting DNA Channels
Authors NOVOTNÝ, Jan (203 Czech Republic, belonging to the institution), Petr KULHÁNEK (203 Czech Republic, belonging to the institution) and Radek MAREK (203 Czech Republic, guarantor, belonging to the institution).
Edition The Journal of Physical Chemistry Letters, Washington, American Chemical Society, 2012, 1948-7185.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW DOI: 10.1021/jz300559w
Impact factor Impact factor: 6.585
RIV identification code RIV/00216224:14740/12:00060331
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1021/jz300559w
UT WoS 000306251900011
Keywords (in Czech) molekulová dynamika; guanin; potenciál střední síly; přenos iontu; volná energie
Keywords in English molecular dynamics; guanine; adaptive biasing force; ion transport; free-energy
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Radek Marek, Ph.D., učo 381. Changed: 14/11/2017 08:32.
Abstract
Molecular dynamics simulations and adaptive biasing force analysis of the quadruplex DNA dynamics in an explicit solvent reveal fundamentally different mechanisms of Na+ transport in xanthine- and guanine-based DNA systems. The barrier to the transport of K+ through the xanthine-based quadruplex is significantly lower than those reported for the guanine-based analogs.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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