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@article{987319, author = {Pávková Goldbergová, Monika and Lipková, Jolana and Pávek, Nikolas and Gatterová, Jindra and Vašků, Anna and Souček, Miroslav and Němec, Petr}, article_number = {3-4}, doi = {http://dx.doi.org/10.1016/j.molimm.2012.06.006}, keywords = {Rheumatoid arthritis; MCP-1; RANTES; Circulating levels; Polymorphism}, language = {eng}, issn = {0161-5890}, journal = {Molecular Immunology}, title = {RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis}, volume = {52}, year = {2012} }
TY - JOUR ID - 987319 AU - Pávková Goldbergová, Monika - Lipková, Jolana - Pávek, Nikolas - Gatterová, Jindra - Vašků, Anna - Souček, Miroslav - Němec, Petr PY - 2012 TI - RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis JF - Molecular Immunology VL - 52 IS - 3-4 SP - 273– 278 EP - 273– 278 SN - 01615890 KW - Rheumatoid arthritis KW - MCP-1 KW - RANTES KW - Circulating levels KW - Polymorphism N2 - The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractants involved in immunoregulatory and inflammatory processes of rheumatoid arthritis. Recent studies demonstrated elevated levels of MCP-1 and RANTES in plasma, synovial fluid, and the synovial tissue of patients with RA. To examine the relationship among MCP-1 and RANTES single nucleotide polymorphisms and circulating levels and rheumatoid arthritis (RA), a total of 156 RA patients and 125 controls were recruited into the study. An association of -855 C/G MCP-1 polymorphism to IgM RF within the RA patients was observed. The lowest circulating levels of RANTES were observed in the AA variant of RANTES -403 G/A polymorphism. Furthermore, an association of -403 AA variant to circulating levels of IL-15 and IL-10 was found. No associations of factors describing rheumatoid arthritis (RFs, ANA, anti-CCP-positive/negative, DAS 28 score and number of swollen joints) with MCP-1 levels, genotype distribution, allelic frequencies and/or frequencies of haplotypes composed of all three studied polymorphisms in promoter region of MCP-1, and RANTES polymorphism were observed. We conclude that the RANTES promoter polymorphism is associated to circulating levels of RANTES, IL15 and IL10. However, our findings suggest that polymorphisms in the MCP-1 and RANTES gene promoters do not contribute significantly to the interindividual RA susceptibility and/or severity in Caucasians. ER -
PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Nikolas PÁVEK, Jindra GATTEROVÁ, Anna VAŠKŮ, Miroslav SOUČEK and Petr NĚMEC. RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis. \textit{Molecular Immunology}. vol.~52, 3-4, p.~273– 278. ISSN~0161-5890. doi:10.1016/j.molimm.2012.06.006. 2012.
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