PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Nikolas PÁVEK, Jindra GATTEROVÁ, Anna VAŠKŮ, Miroslav SOUČEK and Petr NĚMEC. RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis. Molecular Immunology. 2012, vol. 52, 3-4, p. 273– 278. ISSN 0161-5890. doi:10.1016/j.molimm.2012.06.006.
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Basic information
Original name RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis
Authors PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Nikolas PÁVEK (203 Czech Republic, belonging to the institution), Jindra GATTEROVÁ (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic, belonging to the institution) and Petr NĚMEC (203 Czech Republic, belonging to the institution).
Edition Molecular Immunology, 2012, 0161-5890.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.645
RIV identification code RIV/00216224:14110/12:00060402
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.molimm.2012.06.006
UT WoS 000307489800023
Keywords in English Rheumatoid arthritis; MCP-1; RANTES; Circulating levels; Polymorphism
Tags International impact
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 1. 3. 2013 14:20.
Abstract
The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractants involved in immunoregulatory and inflammatory processes of rheumatoid arthritis. Recent studies demonstrated elevated levels of MCP-1 and RANTES in plasma, synovial fluid, and the synovial tissue of patients with RA. To examine the relationship among MCP-1 and RANTES single nucleotide polymorphisms and circulating levels and rheumatoid arthritis (RA), a total of 156 RA patients and 125 controls were recruited into the study. An association of -855 C/G MCP-1 polymorphism to IgM RF within the RA patients was observed. The lowest circulating levels of RANTES were observed in the AA variant of RANTES -403 G/A polymorphism. Furthermore, an association of -403 AA variant to circulating levels of IL-15 and IL-10 was found. No associations of factors describing rheumatoid arthritis (RFs, ANA, anti-CCP-positive/negative, DAS 28 score and number of swollen joints) with MCP-1 levels, genotype distribution, allelic frequencies and/or frequencies of haplotypes composed of all three studied polymorphisms in promoter region of MCP-1, and RANTES polymorphism were observed. We conclude that the RANTES promoter polymorphism is associated to circulating levels of RANTES, IL15 and IL10. However, our findings suggest that polymorphisms in the MCP-1 and RANTES gene promoters do not contribute significantly to the interindividual RA susceptibility and/or severity in Caucasians.
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