Informační systém MU
THON, Vojtěch, Marcela VLKOVÁ, Zita CHOVANCOVÁ, Jiří LITZMAN and Jindřich LOKAJ. Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia. In Clinical Flow Cytometry - Emerging Applications. Rijeka: InTech, 2012. p. 125-142. Biochemistry, Genetics and Molecular Biology. ISBN 978-953-51-0575-6.
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Basic information
Original name Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia
Authors THON, Vojtěch (203 Czech Republic, guarantor, belonging to the institution), Marcela VLKOVÁ (203 Czech Republic, belonging to the institution), Zita CHOVANCOVÁ (203 Czech Republic, belonging to the institution), Jiří LITZMAN (203 Czech Republic, belonging to the institution) and Jindřich LOKAJ (203 Czech Republic, belonging to the institution).
Edition Rijeka, Clinical Flow Cytometry - Emerging Applications, p. 125-142, 18 pp. Biochemistry, Genetics and Molecular Biology, 2012.
Publisher InTech
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30102 Immunology
Country of publisher Croatia
Confidentiality degree is not subject to a state or trade secret
Publication form electronic version available online
WWW URL
RIV identification code RIV/00216224:14110/12:00060403
Organization unit Faculty of Medicine
ISBN 978-953-51-0575-6
Keywords in English Peripheral Blood; Diagnostics; Hypogammaglobulinaemia; Flow Based Enumeration
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 20/4/2013 10:40.
Abstract
Hypogammaglobulinaemic patients are often started on immunoglobulin substitution therapy before antibody production is adequately evaluated. In such a situation, it is difficult to segregate transferred from antigen-induced specific antibody. Therefore we characterized changes in B-cell subpopulations in hypogammaglobulinaemic patients, including plasmablasts, in peripheral blood by flow cytometry after in vivo antigen challenge. We investigated the specificity of antibody production on the B-cell level by ELISPOT, which is independent of substitution therapy.
Links
7E08062, research and development projectName: Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes
Investor: Ministry of Education, Youth and Sports of the CR, Subvention of the projects of the Seventh Framework Programme of the European Community for research, technological development including demonstration activities (2007-2013)
Displayed: 12/5/2021 20:51