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@article{987330,
author = {Sztalmachová, Markéta and Hlavna, Marián and Gumulec, Jaromír and Holubová, Monika and Babula, Petr and Balvan, Jan and Sochor, Jiří and Tanhäuserová, Veronika and Raudenská, Martina and Křížková, Soňa and Adam, Vojtěch and Eckschlager, Tomáš and Kizek, René and Masařík, Michal},
article_number = {3},
doi = {http://dx.doi.org/10.3892/or.2012.1897},
keywords = {apoptosis; prostate cancer; prognostic marker; Bcl-2; p53; polymerase chain reaction; thiol group; fluorescence microscopy},
language = {eng},
issn = {1021-335X},
journal = {Oncology Reports},
title = {Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells},
volume = {28},
year = {2012}
}
TY - JOUR
ID - 987330
AU - Sztalmachová, Markéta - Hlavna, Marián - Gumulec, Jaromír - Holubová, Monika - Babula, Petr - Balvan, Jan - Sochor, Jiří - Tanhäuserová, Veronika - Raudenská, Martina - Křížková, Soňa - Adam, Vojtěch - Eckschlager, Tomáš - Kizek, René - Masařík, Michal
PY - 2012
TI - Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells
JF - Oncology Reports
VL - 28
IS - 3
SP - 806-814
EP - 806-814
SN - 1021335X
KW - apoptosis
KW - prostate cancer
KW - prognostic marker
KW - Bcl-2
KW - p53
KW - polymerase chain reaction
KW - thiol group
KW - fluorescence microscopy
N2 - Several typical characteristics of prostate tissue have been identified including the ability to accumulate zinc(II). However, this feature of prostate cells is lost during carcinogenesis and, thus, prostate cells are unable to accumulate zinc(II) ions in high levels. Therefore, we can expect that zinc(II) ions can significantly contribute to the progression of tumour disease and to the ability of prostate cell lines to metastasize. In this study, we aimed our attention on determining the expression of Bcl-2, c-Fos, c-Jun, Ki-67, NF-xB and p53 genes in two prostate cell lines, as the 22Rv1 cell line, a model of aggressive partially androgen-sensitive prostate cancer and the PNT1A cell line, a normal prostate cell line model. Moreover, we were interested in the mechanisms through which exposure of these cell lines to zinc(II) ions could influence expression of the above-mentioned genes. We found that zinc(II) ions caused elevated expression of Ki-67, a marker of proliferation, extremely low expression of p53, high expression of Bcl-2 and no changes in the expression of p53. Our experimental data show different effect of zinc(II) ions on expression of the above-mentioned regulatory genes, which may give us more information on their impact on cancer development and progression with possible using for cancer therapy.
ER -
SZTALMACHOVÁ, Markéta, Marián HLAVNA, Jaromír GUMULEC, Monika HOLUBOVÁ, Petr BABULA, Jan BALVAN, Jiří SOCHOR, Veronika TANHÄUSEROVÁ, Martina RAUDENSKÁ, Soňa KŘÍŽKOVÁ, Vojtěch ADAM, Tomáš ECKSCHLAGER, René KIZEK and Michal MASAŘÍK. Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells. \textit{Oncology Reports}. 2012, vol.~28, No~3, p.~806-814. ISSN~1021-335X. Available from: https://dx.doi.org/10.3892/or.2012.1897.
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