BÉBAROVÁ, Markéta. Advances in patch clamp technique: towards higher quality and quantity. General physiology and biophysics. GENERAL PHYSIOL AND BIOPHYSICS, 2012, vol. 31, No 2, p. 131-140. ISSN 0231-5882. Available from: https://dx.doi.org/10.4149/gpb_2012_016.
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Basic information
Original name Advances in patch clamp technique: towards higher quality and quantity
Authors BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution).
Edition General physiology and biophysics, GENERAL PHYSIOL AND BIOPHYSICS, 2012, 0231-5882.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.852
RIV identification code RIV/00216224:14110/12:00060414
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.4149/gpb_2012_016
UT WoS 000305315600002
Keywords in English Action potential clamp; Dynamic clamp; Cell-type transforming clamp; High-resolution scanning patch clamp; Automated patch clamp
Tags International impact, Reviewed
Changed by Changed by: doc. MUDr. Markéta Bébarová, Ph.D., učo 15000. Changed: 17/8/2017 17:40.
Abstract
The patch clamp technique, developed in late 1970s, started a new period of experimental cardiac electrophysiology enabling measurement of ionic currents on isolated cardiomyocytes down to the level of single channels. Since that time, the technique has been substantially improved by development of several upgraded modifications providing so far unavailable data (e.g. action potential clamp, dynamic clamp, high-resolution scanning patch clamp), or facilitating the patch clamp technique by increasing its efficiency (planar patch clamp, automated patch clamp). The current review summarizes the leading new patch clamp based techniques used in cardiac cellular electrophysiology, their principles and prominent related papers.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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