J 2012

Chronobiologically Interpreted Ambulatory Blood Pressure Monitoring in Health and Disease

HALBERG, Franz, Germaine CORNÉLISSEN, Dewayne HILLMAN, Larry A. BEATY, Shiyu HONG et. al.

Basic information

Original name

Chronobiologically Interpreted Ambulatory Blood Pressure Monitoring in Health and Disease

Authors

HALBERG, Franz (840 United States of America, guarantor), Germaine CORNÉLISSEN (840 United States of America), Dewayne HILLMAN (840 United States of America), Larry A. BEATY (840 United States of America), Shiyu HONG (840 United States of America), Othild SCHWARTZKOPFF (840 United States of America), Yoshihiko WATANABE (392 Japan), Kuniaki OTSIKA (392 Japan) and Jarmila SIEGELOVÁ (203 Czech Republic, belonging to the institution)

Edition

Global Advances in Health and Medicine, 2012, 2164-9561

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/12:00060416

Organization unit

Faculty of Medicine

Keywords in English

Chronobiology; ambulatory blood pressure; hypertension;circadian; coherence; C-ABPM; stress; vascular variability anomaly; disorder; syndrome
Změněno: 17/7/2012 09:42, Mgr. Michal Petr

Abstract

V originále

To detect vascular variability anomalies (WAs), a blood pressure and heart rate profile around the clock for at least 7 days is a start. As a minimum, measurement every 60 preferably 30 minutes for a week is needed, to be continued if abnormality is found, to assess the about 24-hour (circadian) variability that exists in all individuals. As a first dividend, one then also obtains a glimpse of 2 of the very many longer-than-circadian periodicities, the biological half-week and week. Certainly if we can have sensors and computer chips in our cars that continuously monitor the pressure over a life, we should be able to do the same job for ourselves for diagnostic and therapeutic decisions. Healthcare today emphasizes wellness with recommendations for exercise and a proper diet, yet these evaluations may not be adequate. BP maybe measured at a visit to the doctor or before an exercise session, along with measuring body weight and performing a physical exam. The seeds of disease are planted long before they are visible, and what appears to be normal from a conventional point of view may in fact be abnormal. Hidden alterations of physiological function, masked by the bodys remarkable adaptive capabilities, may become visible through a new diagnostic and therapeutic realm-chronobiology that reveals hitherto unseen abnormalities. The tools of chronobiology may yield additional dividends, such as the detection of physiological "loads" related to stress and stress relief and the undesirable effects of space weather upon personal events such as sudden cardiac death, societal events like terrorism and war, and natural disasters. Chronobiologically interpreted automatic ambulatory BP and heart rate (HR) monitoring (C-ABPM) may detect the antecedents of these types of events, C-ABPM is of interest in preventive cardiology, since it reveals new diagnoses as vascular variability anomalies (WAs) and renders previous conventional diagnoses more reliable, such as that of an elevated BE. These WAs include MESOR (midline-estimating statistic of rhythm)-hypertension, an elevation of the MESOR, which is diagnosed, like all other WAs, only after I or preferably several replications of 7-day around-the-clock BP monitoring with available, affordable, and unobtrusive instrumentation. The recommendation for continuous C-ABPM recognizes several principles that constitute inseparably intertwined contributors to severe cardio-, cerebro- and renovascular diesase, C-ABPM gauges wear and tear of genetics, physical loads, and in particular mental stress placed upon individuals from "womb to tomb" by daily life, including weather in extra-terrestrial spáce as well as that on earth, as a continuous surveillance paradigm preventing us from flying blind to a change from less than 5% to near 100% in the risk of a stroke within 6 years.