| VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan SITAR, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ and Jiří VÍTOVEC. Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease. DISEASE MARKERS. AMSTERDAM: IOS PRESS, 2012, vol. 33, No 1, p. 43-49. ISSN 0278-0240. Available from: https://dx.doi.org/10.3233/DMA-2012-0902. |
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@article{987363,
author = {Vašků, Anna and Meluzín, Jaroslav and Blahák, Jiří and Kincl, Vladimír and Pávková Goldbergová, Monika and Sitar, Jan and Zlámal, Filip and Bienertová Vašků, Julie and Vítovec, Jiří},
article_location = {AMSTERDAM},
article_number = {1},
doi = {http://dx.doi.org/10.3233/DMA-2012-0902},
keywords = {MMP-13; CAD; rs640198; severity},
language = {eng},
issn = {0278-0240},
journal = {DISEASE MARKERS},
title = {Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease},
volume = {33},
year = {2012}
}
TY - JOUR
ID - 987363
AU - Vašků, Anna - Meluzín, Jaroslav - Blahák, Jiří - Kincl, Vladimír - Pávková Goldbergová, Monika - Sitar, Jan - Zlámal, Filip - Bienertová Vašků, Julie - Vítovec, Jiří
PY - 2012
TI - Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease
JF - DISEASE MARKERS
VL - 33
IS - 1
SP - 43-49
EP - 43-49
PB - IOS PRESS
SN - 02780240
KW - MMP-13
KW - CAD
KW - rs640198
KW - severity
N2 - Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87). The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.
ER -
VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan SITAR, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ and Jiří VÍTOVEC. Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease. \textit{DISEASE MARKERS}. AMSTERDAM: IOS PRESS, 2012, vol.~33, No~1, p.~43-49. ISSN~0278-0240. Available from: https://dx.doi.org/10.3233/DMA-2012-0902.
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