Matrix metalloproteinase 13 genotype in rs640198 polymorphism
is associated with severe coronary artery disease

J 2012

Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease

VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ et. al.

Basic information

Original name

Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor, belonging to the institution), Jaroslav MELUZÍN (203 Czech Republic, belonging to the institution), Jiří BLAHÁK (203 Czech Republic, belonging to the institution), Vladimír KINCL (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jan SITAR (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution) and Jiří VÍTOVEC (203 Czech Republic, belonging to the institution)

Edition

DISEASE MARKERS, AMSTERDAM, IOS PRESS, 2012, 0278-0240

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.140

RIV identification code

RIV/00216224:14110/12:00064861

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3233/DMA-2012-0902

UT WoS

000305391200005

Keywords in English

MMP-13; CAD; rs640198; severity

Abstract

V originále

Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87). The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.

Links

NS10206, research and development project

Name: Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE a ACE2 s centrálním pulsním tlakem u kardiovaskulárních pacientů

Investor: Ministry of Health of the CR

Citovat

VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan SITAR, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ and Jiří VÍTOVEC. Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease. DISEASE MARKERS. AMSTERDAM: IOS PRESS, 2012, vol. 33, No 1, p. 43-49. ISSN 0278-0240. Available from: https://dx.doi.org/10.3233/DMA-2012-0902.

@article{987363,
   author = {Vašků, Anna and Meluzín, Jaroslav and Blahák, Jiří and Kincl, Vladimír and Pávková Goldbergová, Monika and Sitar, Jan and Zlámal, Filip and Bienertová Vašků, Julie and Vítovec, Jiří},
   article_location = {AMSTERDAM},
   article_number = {1},
   doi = {http://dx.doi.org/10.3233/DMA-2012-0902},
   keywords = {MMP-13; CAD; rs640198; severity},
   language = {eng},
   issn = {0278-0240},
   journal = {DISEASE MARKERS},
   title = {Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease},
   volume = {33},
   year = {2012}
}

TY  - JOUR
ID  - 987363
AU  - Vašků, Anna - Meluzín, Jaroslav - Blahák, Jiří - Kincl, Vladimír - Pávková Goldbergová, Monika - Sitar, Jan - Zlámal, Filip - Bienertová Vašků, Julie - Vítovec, Jiří
PY  - 2012
TI  - Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease
JF  - DISEASE MARKERS
VL  - 33
IS  - 1
SP  - 43-49
EP  - 43-49
PB  - IOS PRESS
SN  - 02780240
KW  - MMP-13
KW  - CAD
KW  - rs640198
KW  - severity
N2  - Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87). The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.
ER  -

VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan SITAR, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ and Jiří VÍTOVEC. Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease. \textit{DISEASE MARKERS}. AMSTERDAM: IOS PRESS, 2012, vol.~33, No~1, p.~43-49. ISSN~0278-0240. Available from: https://dx.doi.org/10.3233/DMA-2012-0902.

Detailed Information on Publication Record