BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Lenka SLOVÁČKOVÁ, Lenka SÁBLÍKOVÁ, Zlata PISKÁČKOVÁ, Martin FOREJT, Zbyněk ŠPLÍCHAL, Filip ZLÁMAL and Anna VAŠKŮ. Variability in CNR1 locus influences protein intake and smoking status in the Central-European population. Nutritional Neuroscience. Anglie: W. S. Maney and Son, Ltd, 2012, vol. 15, No 4, p. 163-170. ISSN 1028-415X. doi:10.1179/1476830512Y.0000000001.
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Original name Variability in CNR1 locus influences protein intake and smoking status in the Central-European population
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic, belonging to the institution), Lenka SLOVÁČKOVÁ (203 Czech Republic, belonging to the institution), Lenka SÁBLÍKOVÁ (203 Czech Republic, belonging to the institution), Zlata PISKÁČKOVÁ (203 Czech Republic, belonging to the institution), Martin FOREJT (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition Nutritional Neuroscience, Anglie, W. S. Maney and Son, Ltd, 2012, 1028-415X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.647
RIV identification code RIV/00216224:14110/12:00060422
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1179/1476830512Y.0000000001
UT WoS 000306436000002
Keywords in English Endocannabinoids; SNP; Dietary composition; Macronutrients; Gene
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 20. 8. 2012 11:43.
Abstract
Objectives: The endocannabinoid receptor 1 (CB1) is encoded by the CNR1 gene and has been recently recognized to play an important role in the regulation of satiety and feeding behaviour with a huge potential of modulating metabolic response and feeding control. The aim of the study was to investigate the potential of three selected single nucleotide polymorphisms (SNPs) in the CNR1 locus on native dietary composition in the Central-European Caucasian population. Methods: A total of 258 unrelated individuals originating from the Central-European Caucasian population were enrolled into the study and rs1049353, rs12720071, and rs806368 polymorphisms in CNR1 locus were examined in these individuals using PCR-based methodology. Body composition was assessed using a bioimpedance method, various anthropometric parameters were investigated (waist and hip circumference, skin folds), and native dietary composition was analysed using 7-day food records as well as a food frequency questionnaire. Results: Allelic variations and common haplotypes in the CNR1 gene were associated with the daily intake of proteins, fluids, and fibre, regardless of the physical activity of the individuals. The common haplotype in the CNR1 gene was associated with self-reported smoking (number of cigarettes per day, smoking years). Discussion: Our results indicate that specific genetic variations in the CNR1 gene may act as susceptibility markers for specific dietary composition in the Central-European population.
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NNS-15-4-97.pdf   File version Petr, M. 20. 8. 2012

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  • a concrete person prof. MUDr. Anna Vašků, CSc., učo 122
  • a concrete person MUDr. Lenka Slováčková, učo 141674
  • a concrete person MUDr. Lenka Mičínová Sáblíková, učo 141974
  • a concrete person Mgr. Zbyněk Šplíchal, Ph.D., učo 151051
  • a concrete person Mgr. Martin Forejt, Ph.D., učo 16739
  • a concrete person prof. MUDr. Julie Dobrovolná, Ph.D., učo 4805
  • a concrete person Bc. Petr Bienert, učo 50773
  • a concrete person Mgr. Michal Petr, učo 65024
  • a concrete person Mgr. Zlata Kapounová, Ph.D., učo 72367
  • a concrete person Mgr. et Mgr. Filip Zlámal, Ph.D., učo 78448
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