Detailed Information on Publication Record
2012
Variability in CNR1 locus influences protein intake and smoking status in the Central-European population
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Lenka SLOVÁČKOVÁ, Lenka SÁBLÍKOVÁ, Zlata PISKÁČKOVÁ et. al.Basic information
Original name
Variability in CNR1 locus influences protein intake and smoking status in the Central-European population
Authors
BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic, belonging to the institution), Lenka SLOVÁČKOVÁ (203 Czech Republic, belonging to the institution), Lenka SÁBLÍKOVÁ (203 Czech Republic, belonging to the institution), Zlata PISKÁČKOVÁ (203 Czech Republic, belonging to the institution), Martin FOREJT (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)
Edition
Nutritional Neuroscience, Anglie, W. S. Maney and Son, Ltd, 2012, 1028-415X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.647
RIV identification code
RIV/00216224:14110/12:00060422
Organization unit
Faculty of Medicine
UT WoS
000306436000002
Keywords in English
Endocannabinoids; SNP; Dietary composition; Macronutrients; Gene
Tags
International impact
Změněno: 20/8/2012 11:43, Mgr. Michal Petr
Abstract
V originále
Objectives: The endocannabinoid receptor 1 (CB1) is encoded by the CNR1 gene and has been recently recognized to play an important role in the regulation of satiety and feeding behaviour with a huge potential of modulating metabolic response and feeding control. The aim of the study was to investigate the potential of three selected single nucleotide polymorphisms (SNPs) in the CNR1 locus on native dietary composition in the Central-European Caucasian population. Methods: A total of 258 unrelated individuals originating from the Central-European Caucasian population were enrolled into the study and rs1049353, rs12720071, and rs806368 polymorphisms in CNR1 locus were examined in these individuals using PCR-based methodology. Body composition was assessed using a bioimpedance method, various anthropometric parameters were investigated (waist and hip circumference, skin folds), and native dietary composition was analysed using 7-day food records as well as a food frequency questionnaire. Results: Allelic variations and common haplotypes in the CNR1 gene were associated with the daily intake of proteins, fluids, and fibre, regardless of the physical activity of the individuals. The common haplotype in the CNR1 gene was associated with self-reported smoking (number of cigarettes per day, smoking years). Discussion: Our results indicate that specific genetic variations in the CNR1 gene may act as susceptibility markers for specific dietary composition in the Central-European population.