BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT and Anna VAŠKŮ. Adiponectin, its cardioprotective effects and genetic variability in relation to restenosis after percutaneous coronary intervention (PCI). In Adiponectin: Production, Regulation and Roles in Disease. New York: Nova Science Publishers, 2012, p. 23-38. Endocrinology Research and Clinical Developments. ISBN 978-1-61942-165-3.
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Basic information
Original name Adiponectin, its cardioprotective effects and genetic variability in relation to restenosis after percutaneous coronary intervention (PCI)
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition New York, Adiponectin: Production, Regulation and Roles in Disease, p. 23-38, 16 pp. Endocrinology Research and Clinical Developments, 2012.
Publisher Nova Science Publishers
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14110/12:00060425
Organization unit Faculty of Medicine
ISBN 978-1-61942-165-3
Keywords in English adiponectin; percutaneous coronary intervention; restenosis; polymorphism
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 10/4/2013 16:01.
Abstract
Restenosis after percutaneous coronary intervention (PCI) represents a major limitation to this procedure and despite large efforts it is still difficult to stratify patients after PCI according to restenosis risk. A wide range of proteins have been investigated in order to establish new diagnostic/prognostic markers of restenosis after PCI, without major effects. Adiponectin, a protein secreted exclusively by the adipose tissue, has recently emerged as an anti-inflammatory, anti-atherogenic, insulin-sensitizing factor providing possible link between white adipose tissue and cardiovascular disease. This crucial role in cardioprotection is mediated via a variety of mechanisms, including inhibition of foam cell formation, expression of antithrombogenic properties and inhibition of smooth muscle cells proliferation, all vital processes in restenosis development. Considering its cardioprotective effects, the role of adiponectin in prediction of adverse cardiovascular events has been studied extensively. However, little attention is paid to adiponectin role in restenosis development after PCI, even though pathophysiology of restenosis covers directly the mechanisms regulated or substantially influenced by adiponectin. The current review describes pathophysiological effects of adiponectin in cardiovascular system, mainly those closely associated with restenosis development and attention is being paid also to the role of genetic variability.
Abstract (in Czech)
Adiponektin a jeho kardioprotektivní účinky.
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