| BABULA, Petr, Michal MASAŘÍK, Vojtech ADAM, Tomas ECKSCHLAGER, Marie STIBOROVA, Libuše TRNKOVÁ, Helena SKUTKOVA, Ivo PROVAZNIK, Jaromir HUBALEK a Rene KIZEK. Mammalian metallothioneins: properties and functions. Metallomics. 2012, roč. 4, č. 8, s. 739–750. ISSN 1756-5901. doi:10.1039/c2mt20081c. |
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@article{988244,
author = {Babula, Petr and Masařík, Michal and Adam, Vojtech and Eckschlager, Tomas and Stiborova, Marie and Trnková, Libuše and Skutkova, Helena and Provaznik, Ivo and Hubalek, Jaromir and Kizek, Rene},
article_number = {8},
doi = {http://dx.doi.org/10.1039/c2mt20081c},
keywords = {metallothionein; mammal; cysteine-rich proteins; antioxidant; cell proliferation},
language = {eng},
issn = {1756-5901},
journal = {Metallomics},
title = {Mammalian metallothioneins: properties and functions},
volume = {4},
year = {2012}
}
TY - JOUR
ID - 988244
AU - Babula, Petr - Masařík, Michal - Adam, Vojtech - Eckschlager, Tomas - Stiborova, Marie - Trnková, Libuše - Skutkova, Helena - Provaznik, Ivo - Hubalek, Jaromir - Kizek, Rene
PY - 2012
TI - Mammalian metallothioneins: properties and functions
JF - Metallomics
VL - 4
IS - 8
SP - 739–750
EP - 739–750
SN - 17565901
KW - metallothionein
KW - mammal
KW - cysteine-rich proteins
KW - antioxidant
KW - cell proliferation
N2 - Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.
ER -
BABULA, Petr, Michal MASAŘÍK, Vojtech ADAM, Tomas ECKSCHLAGER, Marie STIBOROVA, Libuše TRNKOVÁ, Helena SKUTKOVA, Ivo PROVAZNIK, Jaromir HUBALEK a Rene KIZEK. Mammalian metallothioneins: properties and functions. \textit{Metallomics}. 2012, roč.~4, č.~8, s.~739–750. ISSN~1756-5901. doi:10.1039/c2mt20081c.
|
