BABULA, Petr, Michal MASAŘÍK, Vojtech ADAM, Tomas ECKSCHLAGER, Marie STIBOROVA, Libuše TRNKOVÁ, Helena SKUTKOVA, Ivo PROVAZNIK, Jaromir HUBALEK and Rene KIZEK. Mammalian metallothioneins: properties and functions. Metallomics. 2012, vol. 4, No 8, p. 739–750. ISSN 1756-5901. doi:10.1039/c2mt20081c.
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Basic information
Original name Mammalian metallothioneins: properties and functions
Authors BABULA, Petr (203 Czech Republic, guarantor), Michal MASAŘÍK (203 Czech Republic, belonging to the institution), Vojtech ADAM (203 Czech Republic), Tomas ECKSCHLAGER (203 Czech Republic), Marie STIBOROVA (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, belonging to the institution), Helena SKUTKOVA (203 Czech Republic), Ivo PROVAZNIK (203 Czech Republic), Jaromir HUBALEK (203 Czech Republic) and Rene KIZEK (203 Czech Republic).
Edition Metallomics, 2012, 1756-5901.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.099
RIV identification code RIV/00216224:14110/12:00060504
Organization unit Faculty of Medicine
UT WoS 000306854900002
Keywords in English metallothionein; mammal; cysteine-rich proteins; antioxidant; cell proliferation
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 31. 7. 2012 10:30.
Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.
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