GRELL, Peter, Pavel FABIAN, M KHOYLOU, Lenka RADOVÁ, Ondřej SLABÝ, Roman HRSTKA, Rostislav VYZULA, Marian HAJDÚCH and Marek SVOBODA. Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. International Journal of Oncology. 2012, 9 pp. ISSN 1019-6439. Available from: https://dx.doi.org/10.3892/ijo.2012.1576. |
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@article{988304, author = {Grell, Peter and Fabian, Pavel and Khoylou, M and Radová, Lenka and Slabý, Ondřej and Hrstka, Roman and Vyzula, Rostislav and Hajdúch, Marian and Svoboda, Marek}, doi = {http://dx.doi.org/10.3892/ijo.2012.1576}, keywords = {breast cancer; HER2 protein; trastuzumab; AKT1 protein; AKT2 protein; prognosis}, language = {eng}, issn = {1019-6439}, journal = {International Journal of Oncology}, title = {Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab.}, year = {2012} }
TY - JOUR ID - 988304 AU - Grell, Peter - Fabian, Pavel - Khoylou, M - Radová, Lenka - Slabý, Ondřej - Hrstka, Roman - Vyzula, Rostislav - Hajdúch, Marian - Svoboda, Marek PY - 2012 TI - Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. JF - International Journal of Oncology SN - 10196439 KW - breast cancer KW - HER2 protein KW - trastuzumab KW - AKT1 protein KW - AKT2 protein KW - prognosis N2 - Trastuzumab is effective in about half of HER2- positive breast cancer patients. The PI3K/Akt signalling pathway plays an important role in the process of primary and secondary resistance to anti-HER2 targeted therapy. We evaluated the relationship between expression, activation and subcellular localization of selected Akt isoforms and response to trastuzumab-based anti-HER2 targeted therapy in patients with HER2-positive metastatic breast cancer. ER -
GRELL, Peter, Pavel FABIAN, M KHOYLOU, Lenka RADOVÁ, Ondřej SLABÝ, Roman HRSTKA, Rostislav VYZULA, Marian HAJDÚCH and Marek SVOBODA. Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. \textit{International Journal of Oncology}. 2012, 9 pp. ISSN~1019-6439. Available from: https://dx.doi.org/10.3892/ijo.2012.1576.
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