Changes in concentrations of hydrophilic organic contaminants
and of endocrine-disrupting potential downstream of small
communities located adjacent to headwaters.

J 2012

Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters.

JAROŠOVÁ, Barbora; Luděk BLÁHA; Branislav VRANA; T. RANDÁK; R. GRABIC et. al.

Basic information

Original name

Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters.

Authors

JAROŠOVÁ, Barbora (203 Czech Republic, belonging to the institution); Luděk BLÁHA (203 Czech Republic, belonging to the institution); Branislav VRANA (703 Slovakia, belonging to the institution); T. RANDÁK (203 Czech Republic); R. GRABIC (203 Czech Republic); J. P. GIESY (124 Canada) and Klára HILSCHEROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Environment International, OXFORD, ENGLAND, PERGAMON-ELSEVIER SCIENCE LTD, 2012, 0160-4120

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10511 Environmental sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 6.248

RIV identification code

RIV/00216224:14310/12:00060517

Organization unit

Faculty of Science

DOI

https://doi.org/10.1016/j.envint.2012.04.001

UT WoS

000305728700004

Keywords in English

Androgen; Dioxin-like activity; Estrogen; In vitro assay; POCIS; Waste Water Treatment Plant

Abstract

In the original language

Endocrine-disruptive potential and concentrations of polar organic contaminants were measured in seven headwaters flowing through relatively unpolluted areas of the Czech Republic. Towns with Wastewater Treatment Plant (WWTP) discharges were the first known sources of anthropogenic pollution in the areas. River water was sampled several kilometers upstream (US) and several tens of meters downstream (DS) of the WWTP discharges, by use of Pesticide and Pharmaceutical Polar Organic Integrative Samplers (POCIS-Pest, POCIS-Pharm). Extracts of passive samplers were tested by use of a battery of in vitro bioassays to determine overall non-specific cytotoxicity, endocrine-disruptive (ED) potential and dioxin-like toxicity. The extracts were also used for quantification of polar organics. There was little toxicity to cells caused by most extracts of POCIS. Estrogenicity was detected in all types of samples even though US locations are considered to be background. At US locations, concentrations of estrogen equivalents (EEq) ranged from less than the detection limits (LOD) to 0.5 ng EEq/POCIS. Downstream concentrations of EEqs ranged from less than LOD to 4.8 ng EEq/POCIS. Concentrations of EEq in POCIS extracts from all DS locations were 1 to 14 times greater than those at US locations. Concentrations of EEq measured in extracts of POCIS-Pest and POCIS-Pharm were in a good agreement. Neither antiestrogenic nor anti/androgenic activities were detected. Concentrations of 2.3.7.8-TCDD equivalents (TEq(bio)) were detected in both types of POCIS at Concentrations ranging from less than the LOD to 0.39 ng TEq(bio)/POCIS. Nearly all extracts of POCIS-Pharm contained greater concentrations of TEq(bio) activity than extracts of POCIS-Pest. Concentrations of pesticides and pharmaceuticals in extracts of POCIS were generally small at all sampling sites, but levels of some pharmaceuticals were significantly greater in both types of POCIS from DS locations.

Links

ED0001/01/01, research and development project

Name: CETOCOEN

MSM0021622412, plan (intention)

Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)

2B08036, research and development project

Name: Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů (Acronym: ENVISCREEN)

Investor: Ministry of Education, Youth and Sports of the CR, New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.

Cite

JAROŠOVÁ, Barbora; Luděk BLÁHA; Branislav VRANA; T. RANDÁK; R. GRABIC; J. P. GIESY and Klára HILSCHEROVÁ. Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters. Environment International. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2012, vol. 45, SEPTEMBER, p. 22-31. ISSN 0160-4120. Available from: https://doi.org/10.1016/j.envint.2012.04.001.

@article{988309,
   author = {Jarošová, Barbora and Bláha, Luděk and Vrana, Branislav and Randák, T. and Grabic, R. and Giesy, J. P. and Hilscherová, Klára},
   article_location = {OXFORD, ENGLAND},
   article_number = {SEPTEMBER},
   doi = {https://doi.org/10.1016/j.envint.2012.04.001},
   keywords = {Androgen; Dioxin-like activity; Estrogen; In vitro assay; POCIS; Waste Water Treatment Plant},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters.},
   volume = {45},
   year = {2012}
}

TY  - JOUR
ID  - 988309
AU  - Jarošová, Barbora - Bláha, Luděk - Vrana, Branislav - Randák, T. - Grabic, R. - Giesy, J. P. - Hilscherová, Klára
PY  - 2012
TI  - Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters.
JF  - Environment International
VL  - 45
IS  - SEPTEMBER
SP  - 22-31
EP  - 22-31
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 01604120
KW  - Androgen
KW  - Dioxin-like activity
KW  - Estrogen
KW  - In vitro assay
KW  - POCIS
KW  - Waste Water Treatment Plant
N2  - Endocrine-disruptive potential and concentrations of polar organic contaminants were measured in seven headwaters flowing through relatively unpolluted areas of the Czech Republic. Towns with Wastewater Treatment Plant (WWTP) discharges were the first known sources of anthropogenic pollution in the areas. River water was sampled several kilometers upstream (US) and several tens of meters downstream (DS) of the WWTP discharges, by use of Pesticide and Pharmaceutical Polar Organic Integrative Samplers (POCIS-Pest, POCIS-Pharm). Extracts of passive samplers were tested by use of a battery of in vitro bioassays to determine overall non-specific cytotoxicity, endocrine-disruptive (ED) potential and dioxin-like toxicity. The extracts were also used for quantification of polar organics. There was little toxicity to cells caused by most extracts of POCIS. Estrogenicity was detected in all types of samples even though US locations are considered to be background. At US locations, concentrations of estrogen equivalents (EEq) ranged from less than the detection limits (LOD) to 0.5 ng EEq/POCIS. Downstream concentrations of EEqs ranged from less than LOD to 4.8 ng EEq/POCIS. Concentrations of EEq in POCIS extracts from all DS locations were 1 to 14 times greater than those at US locations. Concentrations of EEq measured in extracts of POCIS-Pest and POCIS-Pharm were in a good agreement. Neither antiestrogenic nor anti/androgenic activities were detected. Concentrations of 2.3.7.8-TCDD equivalents (TEq(bio)) were detected in both types of POCIS at Concentrations ranging from less than the LOD to 0.39 ng TEq(bio)/POCIS. Nearly all extracts of POCIS-Pharm contained greater concentrations of TEq(bio) activity than extracts of POCIS-Pest. Concentrations of pesticides and pharmaceuticals in extracts of POCIS were generally small at all sampling sites, but levels of some pharmaceuticals were significantly greater in both types of POCIS from DS locations.
ER  -

JAROŠOVÁ, Barbora; Luděk BLÁHA; Branislav VRANA; T. RANDÁK; R. GRABIC; J. P. GIESY and Klára HILSCHEROVÁ. Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters. \textit{Environment International}. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2012, vol.~45, SEPTEMBER, p.~22-31. ISSN~0160-4120. Available from: https://doi.org/10.1016/j.envint.2012.04.001.

Přehled o publikaci