KUBÍKOVÁ, Radka, Mojmír TYRLÍK and Irena REKTOROVÁ. Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease. Ceska a Slovenska Neurologie a Neurochirurgie. Czech Medical Association J.E. Purkyne, 2011, vol. 74, No 4, p. 463-466. ISSN 1210-7859.
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Basic information
Original name Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease
Authors KUBÍKOVÁ, Radka (203 Czech Republic, belonging to the institution), Mojmír TYRLÍK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Ceska a Slovenska Neurologie a Neurochirurgie, Czech Medical Association J.E. Purkyne, 2011, 1210-7859.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.279
RIV identification code RIV/00216224:14740/11:00060542
Organization unit Central European Institute of Technology
UT WoS 000294035900009
Keywords in English Affective; Apomorphine; Cognitive; Dementia; Parkinson's disease
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 23. 4. 2013 07:30.
Abstract
Aims: To determine whether long-term treatment with continuous subcutaneous apomorphine infusions (CSAI) is safe for patients with Parkinson's disease (PD) with a history of hallucinations and/or marked cognitive deficit. Methods: 12 PD patients (9 men, 3 women; age 71.8 +- 6 years) were given neuropsychological assessment prior to continuous administration of CSAI and fourteen months after it. Results: CSAI led to clinical improvement, at least minimal, in all subjects. However, the treatment led to statistically significant impairment in verbal fluency tasks, the Mattis dementia rating scale (MDRS) score and the attention and initiation subtests. No mood changes were detected. Conclusions: We observed significant impairment in "frontal-like" tasks after continuous treatment with CSAI in our PD patients with baseline cognitive impairment. Further longitudinal controlled studies are needed to assess the impact of both CSAI and PD progression. We suggest cautious selection of patients eligible for CSAI therapy with respect to their cognitive profiles and/or neuropsychiatric complications.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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