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@article{989155,
author = {Vorlíčková, Michaela and Kejnovská, Iva and Sagi, Janos and Renčiuk, Daniel and Bednářová, Klára and Motlová, Jitka and Kypr, Jaroslav},
article_location = {SAN DIEGO},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.ymeth.2012.03.011},
keywords = {Polymorphism of quadruplex arrangements; DNA; RNA; CD spectra and structure of nucleic acids; Duplexes and tetraplexes; Cooperative and non-cooperative DNA transitions; Guanine-rich genomic sequences},
language = {eng},
issn = {1046-2023},
journal = {Methods},
title = {Circular dichroism and guanine quadruplexes},
url = {http://www.sciencedirect.com/science/article/pii/S1046202312000679},
volume = {57},
year = {2012}
}
TY - JOUR
ID - 989155
AU - Vorlíčková, Michaela - Kejnovská, Iva - Sagi, Janos - Renčiuk, Daniel - Bednářová, Klára - Motlová, Jitka - Kypr, Jaroslav
PY - 2012
TI - Circular dichroism and guanine quadruplexes
JF - Methods
VL - 57
IS - 1
SP - 64-75
EP - 64-75
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 10462023
KW - Polymorphism of quadruplex arrangements
KW - DNA
KW - RNA
KW - CD spectra and structure of nucleic acids
KW - Duplexes and tetraplexes
KW - Cooperative and non-cooperative DNA transitions
KW - Guanine-rich genomic sequences
UR - http://www.sciencedirect.com/science/article/pii/S1046202312000679
L2 - http://www.sciencedirect.com/science/article/pii/S1046202312000679
N2 - Circular dichroism (CD) is remarkably sensitive to the conformational states of nucleic acids; therefore, CD spectroscopy has been used to study most features of DNA and RNA structures. Quadruplexes are among the significant noncanonical nucleic acids architectures that have received special attentions recently. This article presents examples on the contribution of CD spectroscopy to our knowledge of quadruplex structures and their polymorphism. The examples were selected to demonstrate the potential of this simple method in the quadruplex field. As CD spectroscopy detects only the global feature of a macromolecule, it should preferably be used in combination with other techniques. On the other hand, CD spectroscopy, often as a pioneering approach, can reveal the formation of particular structural arrangements, to search for the conditions stabilizing the structures, to follow the transitions between various structural states, to explore kinetics of their appearance, to determine thermodynamic parameters and also detect formation of higher order structures. This article aims to show that CD spectroscopy is an important complementary technique to NMR spectroscopy and X-ray diffraction in quadruplex studies.
ER -
VORLÍČKOVÁ, Michaela, Iva KEJNOVSKÁ, Janos SAGI, Daniel RENČIUK, Klára BEDNÁŘOVÁ, Jitka MOTLOVÁ a Jaroslav KYPR. Circular dichroism and guanine quadruplexes. \textit{Methods}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012, roč.~57, č.~1, s.~64-75. ISSN~1046-2023. doi:10.1016/j.ymeth.2012.03.011.
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