| JUŘICA, Jan, Richard BARTEČEK, Alexandra ŽOURKOVÁ, Eva PINDUROVÁ, Alexandra ŠULCOVÁ, Tomáš KAŠPÁREK and Ondřej ZENDULKA. Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS. HOBOKEN: WILEY-BLACKWELL, 2012, vol. 37, No 4, p. 486-490. ISSN 0269-4727. Available from: https://dx.doi.org/10.1111/j.1365-2710.2012.01333.x. |
Other formats:
BibTeX
LaTeX
RIS
@article{989156,
author = {Juřica, Jan and Barteček, Richard and Žourková, Alexandra and Pindurová, Eva and Šulcová, Alexandra and Kašpárek, Tomáš and Zendulka, Ondřej},
article_location = {HOBOKEN},
article_number = {4},
doi = {http://dx.doi.org/10.1111/j.1365-2710.2012.01333.x},
keywords = {CYP2D6; dextromethorphan; genotype; metabolic ratio; phenotype; serum},
language = {eng},
issn = {0269-4727},
journal = {JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS},
title = {Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice},
url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2012.01333.x/abstract},
volume = {37},
year = {2012}
}
TY - JOUR
ID - 989156
AU - Juřica, Jan - Barteček, Richard - Žourková, Alexandra - Pindurová, Eva - Šulcová, Alexandra - Kašpárek, Tomáš - Zendulka, Ondřej
PY - 2012
TI - Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice
JF - JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
VL - 37
IS - 4
SP - 486-490
EP - 486-490
PB - WILEY-BLACKWELL
SN - 02694727
KW - CYP2D6
KW - dextromethorphan
KW - genotype
KW - metabolic ratio
KW - phenotype
KW - serum
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2012.01333.x/abstract
L2 - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2012.01333.x/abstract
N2 - What is known and Objective: Accurate prediction of actual CYP2D6 metabolic activity may prevent some adverse drug reactions and improve therapeutic response in patients receiving CYP2D6 substrates. Dextromethorphan-to-dextrorphan metabolic ratio (MRDEM/DOR) is well established as a marker of CYP2D6 metabolizer status. The relationship between urine and plasma or serum MRDEM/DOR is not well established nor is there evidence of antimode for separation of intermediate and especially poor metabolizers (PM) from extensive metabolizers (EM). This study addressed whether CYP2D6 phenotyping using molar metabolic ratio of dextromethorphan to dextrorphan (MRDEM/DOR) in serum is usable and reliable in clinical practice as urinary MRDEM/DOR. Methods: We measured MRDEM/DOR in serum and CYP2D6 genotype in 51 drug-naive patients and 30 volunteers. Receiver-operator characteristic (ROC) analysis was used for the evaluation of optimum cut-off value for discriminating between extensive, intermediate and PM. In addition, we studied the correlation of serum MRDEM/DOR with urine MRDEM/DOR in the 30 healthy volunteers. Results and Discussion: A trimodal distribution of log MRDEM/DOR in serum was observed, with substantial overlap between extensive and intermediate metabolizer groups. We obtained an acceptable cut-off serum MRDEM/DOR value to discriminate between PM and either extensive or extensive + intermediate metabolizers. Using serum MRDEM/DOR, it seems to be unreliable to discriminate EM from intermediate metabolizers (IM). A strong correlation between serum MRDEM/DOR and urine MRDEM/DOR was found. What is new and Conclusion: Serum MRDEM/DOR (3 h) correlated with MRDEM/DOR in urine (08 h). Serum MRDEM/DOR discriminated between extensive and PM and between extensive + intermediate and PM. Our CYP2D6 phenotyping using serum dextromethorphan/dextrorphan molar ratio appears reliable but requires independent validation.
ER -
JUŘICA, Jan, Richard BARTEČEK, Alexandra ŽOURKOVÁ, Eva PINDUROVÁ, Alexandra ŠULCOVÁ, Tomáš KAŠPÁREK and Ondřej ZENDULKA. Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice. \textit{JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS}. HOBOKEN: WILEY-BLACKWELL, 2012, vol.~37, No~4, p.~486-490. ISSN~0269-4727. Available from: https://dx.doi.org/10.1111/j.1365-2710.2012.01333.x.
|
