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@article{989192, author = {Smolej, Lukáš and Doubek, Michael and Panovská, Anna and Šimkovič, Martin and Brychtová, Yvona and Belada, David and Motyčková, Monika and Mayer, Jiří}, article_location = {Oxford, UK}, article_number = {10}, doi = {http://dx.doi.org/10.1016/j.leukres.2012.07.005}, keywords = {Chronic lymphocytic leukemia Rituximab Dexamethasone Refractory disease Chemoimmunotherapy Corticosteroids}, language = {eng}, issn = {0145-2126}, journal = {Leukemia Research}, title = {Rituximab in combination with high-dose dexamethasone for the treatment of relapsed/refractory chronic lymphocytic leukemia}, url = {http://www.sciencedirect.com/science/article/pii/S0145212612002925#gs0025}, volume = {36}, year = {2012} }
TY - JOUR ID - 989192 AU - Smolej, Lukáš - Doubek, Michael - Panovská, Anna - Šimkovič, Martin - Brychtová, Yvona - Belada, David - Motyčková, Monika - Mayer, Jiří PY - 2012 TI - Rituximab in combination with high-dose dexamethasone for the treatment of relapsed/refractory chronic lymphocytic leukemia JF - Leukemia Research VL - 36 IS - 10 SP - 1278-1282 EP - 1278-1282 PB - PERGAMON-ELSEVIER SCIENCE LTD SN - 01452126 KW - Chronic lymphocytic leukemia Rituximab Dexamethasone Refractory disease Chemoimmunotherapy Corticosteroids UR - http://www.sciencedirect.com/science/article/pii/S0145212612002925#gs0025 L2 - http://www.sciencedirect.com/science/article/pii/S0145212612002925#gs0025 N2 - High-dose methylprednisolone is active in treatment of relapsed/refractory chronic lymphocytic leukemia (CLL) but infectious toxicity is serious. The aim of this project was to retrospectively assess efficacy and safety of high-dose dexamethasone combined with rituximab (R–dex) in this setting. Patients and methods: We treated 54 patients (pts) with relapsed/refractory CLL using R–dex regimen at two tertiary centers. Two schedules of rituximab were used (not randomized – based on the choice of the center): group 1, rituximab 500 mg/m2 day 1, 8, 15, 22 (375 mg/m2 in 1st dose) every 4 weeks (n = 29); group 2, 500 mg/m2 day 1 (375 mg/m2 in 1st cycle) repeated every 3 weeks (n = 25). The target dose of dexamethasone was 40 mg on days 1–4 and 10–13 or 15–18. Rai III/IV stages were present in 82%, unmutated IgVH genes in 82%, del 11q in 38% and del 17p in 19% pts; 46% had bulky lymph nodes; 82% were pretreated with fludarabine and 29% with alemtuzumab. Results: Overall response rate/complete remissions were 62/21% (Group 1) and 72/4% (Group 2). In three patients, R–dex was successfully used for debulking before nonmyeloablative allogeneic stem cell transplantation. R–dex was particularly effective in improvement of anemia and thrombocytopenia (p = 0.0055 and p = 0.0036); B-symptoms resolved after treatment in 11/17 pts. Hematological toxicity was mild. Serious infections occurred in 32% pts. At the median follow-up of 9 and 10 months, median progression-free survival was 6 months in Group 1 and 6.9 months in Group 2 (p = ns); median overall survival was 14.1 months in Group 1 vs. not reached in Group 2 (p = ns). Conclusions: R–dex appears to be an active and feasible treatment for relapsed/refractory CLL. Infectious toxicity remains an important issue. Further investigation of this regimen in larger studies appears fully warranted. ER -
SMOLEJ, Lukáš, Michael DOUBEK, Anna PANOVSKÁ, Martin ŠIMKOVIČ, Yvona BRYCHTOVÁ, David BELADA, Monika MOTYČKOVÁ a Jiří MAYER. Rituximab in combination with high-dose dexamethasone for the treatment of relapsed/refractory chronic lymphocytic leukemia. \textit{Leukemia Research}. Oxford, UK: PERGAMON-ELSEVIER SCIENCE LTD, roč.~36, č.~10, s.~1278-1282. ISSN~0145-2126. doi:10.1016/j.leukres.2012.07.005. 2012.
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