Vistafin: Association with Genetic Variability in Vistafin
(PBEF) Gene, Anthropometric Parameters and Dietary Composition
in Obese and Non-Obese Central-European Population

a 2012

Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population

BIENERTOVÁ VAŠKŮ, Julie, Jiří ŠŤASTNÝ, Josef TOMANDL, Marie TOMANDLOVÁ, Martin FOREJT et. al.

Basic information

Original name

Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population

Name in Czech

Visfatin: asociace genetické variability v genu pro visfatin s antropometrickými parametry a složení stravy u obézní a neobézní středoevropské populace

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Jiří ŠŤASTNÝ (203 Czech Republic), Josef TOMANDL (203 Czech Republic), Marie TOMANDLOVÁ (203 Czech Republic), Martin FOREJT (203 Czech Republic), Zbyněk ŠPLÍCHAL (203 Czech Republic), Petr BIENERT (203 Czech Republic), Dagmar ŠTAFOVÁ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic)

Edition

European Human Genetics Conference 2012, 2012

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30202 Endocrinology and metabolism

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/12:00060619

Organization unit

Faculty of Medicine

Keywords (in Czech)

visfatin; antropometrie; složení stravy; genetická variabilita

Keywords in English

visfatin; anthropometry; dietary composition; genetic variability

Abstract

ORIG CZ

V originále

strong insulin-mimetic activity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. We analyzed a total of 6 exons and adjacent non-coding regions of the PBEF gene in 20 extremely obese Czech individuals using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Plasma levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and in part of the validation cohort. Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G). The rs2302559 showed significant correlation with visfatin plasma level throughout the entire study cohort; there was a significant tendency towards higher visfatin levels in G allele carriers with GG homozygotes having the highest visfatin plasma levels. Furthermore, a negative correlation was observed between visfatin and leptin plasma level (p = 0.01). No association between investigated SNPs and anthropometric parameters or native dietary composition was observed. This is the first study to demonstrate that the rs2302559 polymorphism in the PBEF gene is related to circulating levels of visfatin.

In Czech

Jedná se o první studii prokazující, že variabilita v genu pro visfatin může ovlivňovat nativní stravovací chování u člověka.

Links

MUNI/A/0831/2011, interní kód MU

Name: Příspěvek chemických a biochemických metodik ke studiu molekulární podstaty vybraných patologických stavů a onemocnění

Investor: Masaryk University, Category A

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Jiří ŠŤASTNÝ, Josef TOMANDL, Marie TOMANDLOVÁ, Martin FOREJT, Zbyněk ŠPLÍCHAL, Petr BIENERT, Dagmar ŠTAFOVÁ and Anna VAŠKŮ. Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population. In European Human Genetics Conference 2012. 2012.

@proceedings{989334,
   author = {Bienertová Vašků, Julie and Šťastný, Jiří and Tomandl, Josef and Tomandlová, Marie and Forejt, Martin and Šplíchal, Zbyněk and Bienert, Petr and Štafová, Dagmar and Vašků, Anna},
   booktitle = {European Human Genetics Conference 2012},
   keywords = {visfatin; anthropometry; dietary composition; genetic variability},
   language = {eng},
   title = {Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population},
   year = {2012}
}

TY  - CONF
ID  - 989334
AU  - Bienertová Vašků, Julie - Šťastný, Jiří - Tomandl, Josef - Tomandlová, Marie - Forejt, Martin - Šplíchal, Zbyněk - Bienert, Petr - Štafová, Dagmar - Vašků, Anna
PY  - 2012
TI  - Vistafin: Association with Genetic Variability in Vistafin (PBEF) Gene, Anthropometric Parameters and Dietary Composition in Obese and Non-Obese Central-European Population
KW  - visfatin
KW  - anthropometry
KW  - dietary composition
KW  - genetic variability
N2  - strong insulin-mimetic activity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. We analyzed a total of 6 exons and adjacent non-coding regions of the PBEF gene in 20 extremely obese Czech individuals using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Plasma levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and in part of the validation cohort. Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G). The rs2302559 showed significant correlation with visfatin plasma level throughout the entire study cohort; there was a significant tendency towards higher visfatin levels in G allele carriers with GG homozygotes having the highest visfatin plasma levels. Furthermore, a negative correlation was observed between visfatin and leptin plasma level (p = 0.01). No association between investigated SNPs and anthropometric parameters or native dietary composition was observed. This is the first study to demonstrate that the rs2302559 polymorphism in the PBEF gene is related to circulating levels of visfatin.
ER  -

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